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Literature summary for 3.2.1.22 extracted from

  • Mapes, C.A.; Suelter, C.H.; Sweeley, C.C.
    Isolation and characterization of ceramide trihexosidases (form A) from human plasma (1973), J. Biol. Chem., 248, 2471-2479.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
digalactosylceramide in absence of sodium taurocholate and sodium chloride at low substrate concentrations Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ceramide lactoside
-
Homo sapiens
ceramide trihexoside
-
Homo sapiens
digalactosylceramide in presence of optimal sodium taurocholate and sodium chloride or at high substrate concentrations Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24000
-
4 * 24000, SDS-PAGE Homo sapiens
95000
-
sucrose density gradient centrifugation, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O Homo sapiens
-
lactosyl-N-acylsphingosine + D-galactose
-
?

Organic Solvent Stability

Organic Solvent Comment Organism
Butanol A1 retains enzymatic activity in 100% butanol, A2 retains activity in 20% butanol Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
2 forms, non-interconvertible: form A-1, form A-2
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0396
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O
-
Homo sapiens lactosyl-N-acylsphingosine + D-galactose
-
?
additional information p-nitrophenyl-alpha-galactoside Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 24000, SDS-PAGE Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
100
-
A-1 75% loss of activity after boiling, A-2 100% loss of activity after boiling Homo sapiens