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Literature summary for 3.2.1.209 extracted from

  • Termine, D.J.; Moremen, K.W.; Sifers, R.N.
    The mammalian UPR boosts glycoprotein ERAD by suppressing the proteolytic downregulation of ER mannosidase I (2009), J. Cell Sci., 122, 976-984 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UKM7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human alpha1-antitrypsin genetic variant null + H2O substrate misfolds following biosynthesis Homo sapiens ? + D-mannose
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?

Subunits

Subunits Comment Organism
? x * 82000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ER ManI
-
Homo sapiens
ERManI
-
Homo sapiens

General Information

General Information Comment Organism
physiological function overexpression of misfolded protein leads to increased expression of mannosidase ERManI. Expression of ER degradation-enhancing mannosidase-like protein EDEM1 results in stabilization of a higher molecular weight form of ERManI. Knockdown of ERManI, but not EDEM1, diminishes basal endoplasmic reticulum-associated degradation Homo sapiens