Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UKM7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
human alpha1-antitrypsin genetic variant null + H2O | substrate misfolds following biosynthesis | Homo sapiens | ? + D-mannose | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 82000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ER ManI | - |
Homo sapiens |
ERManI | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | overexpression of misfolded protein leads to increased expression of mannosidase ERManI. Expression of ER degradation-enhancing mannosidase-like protein EDEM1 results in stabilization of a higher molecular weight form of ERManI. Knockdown of ERManI, but not EDEM1, diminishes basal endoplasmic reticulum-associated degradation | Homo sapiens |