Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UKM7 | - |
- |
Mus musculus | Q2HXL6 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha1-antitrypsin NHK + H2O | substrate is a variant of alpha1-antitrypsin and substrate for ER-associated degradation of misfolded proteins | Homo sapiens | ? + D-mannose | - |
? | |
glycan residues of alpha1-antitrypsin NHK + H2O | substrate is a variant of alpha1-antitrypsin and substrate for ER-associated degradation of misfolded glycoproteins | Mus musculus | ? + D-mannose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
EDEM3 | - |
Mus musculus |
MAN1B1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | presence of the lectin hOS-9 enhances ER-associated degradation (ERAD) of misfolded glycoproteins, the enhancement depends on the N-glycan structures of the substrate. N-glycans lacking the terminal mannose from the C branch are recognized by hOS-9 and targeted for degradation | Homo sapiens |
physiological function | presence of the lectin hOS-9 enhances ER-associated degradation (ERAD) of misfolded glycoproteins, the enhancement depends on the N-glycan structures of the substrate. N-glycans lacking the terminal mannose from the C branch are recognized by hOS-9 and targeted for degradation | Mus musculus |