Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.209 extracted from

  • Hosokawa, N.; Kamiya, Y.; Kamiya, D.; Kato, K.; Nagata, K.
    Human OS-9, a lectin required for glycoprotein ERAD, recognizes mannose-trimmed N-glycans (2009), J. Biol. Chem., 284, 17061-17068 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.209

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-
endoplasmic reticulum
-
 Mus musculus 5783
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UKM7
-
-
Mus musculus Q2HXL6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha1-antitrypsin NHK + H2O substrate is a variant of alpha1-antitrypsin and substrate for ER-associated degradation of misfolded proteins Homo sapiens ? + D-mannose
-
 ?
glycan residues of alpha1-antitrypsin NHK + H2O substrate is a variant of alpha1-antitrypsin and substrate for ER-associated degradation of misfolded glycoproteins Mus musculus ? + D-mannose
-
 ?

Synonyms

Synonyms Comment Organism
EDEM3
-
 Mus musculus
MAN1B1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function presence of the lectin hOS-9 enhances ER-associated degradation (ERAD) of misfolded glycoproteins, the enhancement depends on the N-glycan structures of the substrate. N-glycans lacking the terminal mannose from the C branch are recognized by hOS-9 and targeted for degradation Homo sapiens
physiological function presence of the lectin hOS-9 enhances ER-associated degradation (ERAD) of misfolded glycoproteins, the enhancement depends on the N-glycan structures of the substrate. N-glycans lacking the terminal mannose from the C branch are recognized by hOS-9 and targeted for degradation Mus musculus