Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.207 extracted from

  • Cumpstey, I.; Ramstadius, C.; Eszter Borbas, K.; Alonzi, D.; Butters, T.
    Synthesis and alpha-glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis (2011), Bioorg. Med. Chem. Lett., 21, 5219-5223 .
    View publication on PubMed
Search for more literature for 3.2.1.207

Inhibitors

Inhibitors Comment Organism Structure
(1S,2S,3R,6S)-6-[[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-4-yl]amino]-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol valienamine-derived N1->3-linked pseudosaccharide Rattus norvegicus
(1S,2S,3R,6S)-6-[[(2R,3S,4S,5S,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-4-yl]amino]-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol valienamine-derived N1->3-linked pseudosaccharide Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Glc2Man9GlcNAc2 + H2O
-
 Rattus norvegicus GlcMan9GlcNAc2 + beta-D-glucopyranose
-
 ?
GlcMan9GlcNAc2 + H2O
-
 Rattus norvegicus Man9GlcNAc2 + beta-D-glucopyranose
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.072
-
 cleavage-1, pH not specified in the publication, temperature not specified in the publication Rattus norvegicus (1S,2S,3R,6S)-6-[[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-4-yl]amino]-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol
0.143
-
 cleavage-2, pH not specified in the publication, temperature not specified in the publication Rattus norvegicus (1S,2S,3R,6S)-6-[[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-4-yl]amino]-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol
0.236
-
 cleavage-2, pH not specified in the publication, temperature not specified in the publication Rattus norvegicus (1S,2S,3R,6S)-6-[[(2R,3S,4S,5S,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-4-yl]amino]-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol