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Literature summary for 3.2.1.207 extracted from

  • Anji, A.; Miller, H.; Raman, C.; Phillips, M.; Ciment, G.; Kumari, M.
    Expression of alpha-subunit of alpha-glucosidase II in adult mouse brain regions and selected organs (2015), J. Neurosci. Res., 93, 82-93.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine inhibitors of the enzyme are used to inhibit cell proliferation and migration in a variety of different pathologies, such as viral infection, cancer, and diabetes Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum the soluble alpha subunit is retained in the endoplasmic reticulum through its interaction with the HDEL-containing beta subunit Mus musculus 5783
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Organism

Organism UniProt Comment Textmining
Mus musculus Q8BHN3
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-
Mus musculus C57BL/6 Q8BHN3
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein N-glycosylation of the enzyme Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain expression of the enzyme in all brain regions Mus musculus
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cerebral cortex higher expression Mus musculus
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heart low expression Mus musculus
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kidney
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Mus musculus
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lung
-
Mus musculus
-
additional information tissue-specific expression pattern of the enzyme, overview Mus musculus
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testis
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the catalytic enzyme alpha subunit, with the help of mannose 6-phosphate receptor homology domain of the beta-subunit, sequentially hydrolyzes two alpha1-3-linked glucose residues in the second step of N-linked oligosaccharide-mediated protein folding Mus musculus ?
-
?
additional information the catalytic enzyme alpha subunit, with the help of mannose 6-phosphate receptor homology domain of the beta-subunit, sequentially hydrolyzes two alpha1-3-linked glucose residues in the second step of N-linked oligosaccharide-mediated protein folding Mus musculus C57BL/6 ?
-
?

Subunits

Subunits Comment Organism
heterodimer alphabeta Mus musculus
More enzyme peptide proteolysis and fragment analysis, overview Mus musculus

Synonyms

Synonyms Comment Organism
alpha-glucosidase II
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Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme is continuously requirement in correct folding of cell surface proteins Mus musculus