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Literature summary for 3.2.1.207 extracted from

  • Takeda, Y.; Totani, K.; Matsuo, I.; Ito, Y.
    The action of bromoconduritol on ER glucosidase II (2010), Bioorg. Med. Chem. Lett., 20, 5357-5359.
    View publication on PubMed
Search for more literature for 3.2.1.207

Inhibitors

Inhibitors Comment Organism Structure
bromoconduritol i.e. 6-bromo-3,4,5-trihydroxycyclohex-1-ene. In the presence of 0.3 mM bromoconduritol the cleavage-2 is strongly inhibited (the consumption of Glc1Man9GlcNAc2 is less than 10% even after 24 h). The consumption of Glc2Man9GlcNAc2 is about 20% after 1 h, while that in the absence of bromoconduritol is about 70%. For the cleavage-1, the extent of inhibition increases as the preincubation time elongates. The binding of bromoconduritol to glucosidase-II is an irreversible and slow process Rattus norvegicus
castanospermine
-
 Rattus norvegicus
deoxynojirimycin
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Rattus norvegicus 5783
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GlcNAcalpha(1->3)GlcNAcalpha(1->3)Manalpha(1->2)Manalpha(1->2)Manalpha(1->3)[Manalpha(1->2)Manalpha(1->6)[Manalpha(1->2)Manalpha(1->3)]Manalpha(1->6)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc-Gly-BODIPY + H2O
-
 Rattus norvegicus GlcNAcalpha(1->3)Manalpha(1->2)Manalpha(1->2)Manalpha(1->3)[Manalpha(1->2)Manalpha(1->6)[Manalpha(1->2)Manalpha(1->3)]Manalpha(1->6)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc-Gly-BODIPY + D-glucose
-
 ?
GlcNAcalpha(1->3)Manalpha(1->2)Manalpha(1->2)Manalpha(1->3)[Manalpha(1->2)Manalpha(1->6)[Manalpha(1->2)Manalpha(1->3)]Manalpha(1->6)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc-Gly-BODIPY + H2O
-
 Rattus norvegicus Manalpha(1->2)Manalpha(1->2)Manalpha(1->3)[Manalpha(1->2)Manalpha(1->6)[Manalpha(1->2)Manalpha(1->3)]Manalpha(1->6)]Manbeta(1->4)GlcNAcbeta(1->4)GlcNAc-Gly-BODIPY + D-glucose
-
 ?

Synonyms

Synonyms Comment Organism
G-II
-
 Rattus norvegicus
glucosidase II
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00082
-
 inhibitory activity of inhibitor against the cleavage-1 reaction, in 10 mM HEPES (pH 7.4), at 37°C Rattus norvegicus deoxynojirimycin
0.0011
-
 inhibitory activity of inhibitor against the cleavage-2 reaction, in 10 mM HEPES (pH 7.4), at 37°C Rattus norvegicus castanospermine
0.0013
-
 inhibitory activity of inhibitor against the cleavage-1 reaction, in 10 mM HEPES (pH 7.4), at 37°C Rattus norvegicus castanospermine
0.0112
-
 inhibitory activity of inhibitor against the cleavage-2 reaction, in 10 mM HEPES (pH 7.4), at 37°C Rattus norvegicus deoxynojirimycin
0.041
-
 inhibitory activity of inhibitor against the cleavage-2 reaction, in 10 mM HEPES (pH 7.4), at 37°C Rattus norvegicus bromoconduritol
0.2616
-
 inhibitory activity of inhibitor against the cleavage-1 reaction, in 10 mM HEPES (pH 7.4), at 37°C Rattus norvegicus bromoconduritol