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Literature summary for 3.2.1.20 extracted from

  • Ryu, H.W.; Lee, B.W.; Curtis-Long, M.J.; Jung, S.; Ryu, Y.B.; Lee, W.S.; Park, K.H.
    Polyphenols from Broussonetia papyrifera displaying potent alpha-glucosidase inhibition (2010), J. Agric. Food Chem., 58, 202-208.
    View publication on PubMed
Search for more literature for 3.2.1.20

Inhibitors

Inhibitors Comment Organism Structure
3'-(3-methylbut-2-enyl)-3',4',7-trihydroxyflavane
-
 Homo sapiens
3,4-dihydroxyisolonchocarpin noncompetitive inhibition Homo sapiens
4-hydroxyisolonchocarpin noncompetitive inhibition Homo sapiens
8-(1,1-dimethylallyl)-5'-(3-methylbut-2-enyl)-3',4',5,7-tetrahydroxyflanvonol
-
 Homo sapiens
Brossoflurenone A
-
 Homo sapiens
Brossoflurenone B
-
 Homo sapiens
Broussochalcone A noncompetitive inhibition Homo sapiens
Broussochalcone B noncompetitive inhibition Homo sapiens
Kazinol A
-
 Homo sapiens
kazinol B
-
 Homo sapiens
Kazinol E
-
 Homo sapiens
papyriflavonol A
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl alpha-D-glucopyranoside + H2O assay at pH 6.8, 37°C, reaction stopped by adding of NaOH Homo sapiens 4-nitrophenol + D-glucose
-
 ?

Synonyms

Synonyms Comment Organism
alpha-glucosidase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0023
-
 papyriflavonol A
-
 Homo sapiens
0.0042
-
 8-(1,1-dimethylallyl)-5'-(3-methylbut-2-enyl)-3',4',5,7-tetrahydroxyflanvonol
-
 Homo sapiens
0.0049
-
 Kazinol E
-
 Homo sapiens
0.0072
-
 Broussochalcone A
-
 Homo sapiens
0.0081
-
 3,4-dihydroxyisolonchocarpin
-
 Homo sapiens
0.0097
-
 4-hydroxyisolonchocarpin
-
 Homo sapiens
0.0121
-
 Brossoflurenone A
-
 Homo sapiens
0.0136
-
 Kazinol A
-
 Homo sapiens
0.0136
-
 Brossoflurenone B
-
 Homo sapiens
0.0162
-
 Broussochalcone B
-
 Homo sapiens
0.0203
-
 kazinol B
-
 Homo sapiens
0.0462
-
 3'-(3-methylbut-2-enyl)-3',4',7-trihydroxyflavane
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0021
-
-
 Homo sapiens papyriflavonol A
0.0036
-
-
 Homo sapiens 8-(1,1-dimethylallyl)-5'-(3-methylbut-2-enyl)-3',4',5,7-tetrahydroxyflanvonol
0.0053
-
-
 Homo sapiens Broussochalcone A
0.0106
-
-
 Homo sapiens Kazinol E
0.0111
-
-
 Homo sapiens Broussochalcone B
0.012
-
-
 Homo sapiens Kazinol A
0.0123
-
-
 Homo sapiens 4-hydroxyisolonchocarpin
0.0191
-
-
 Homo sapiens 3,4-dihydroxyisolonchocarpin
0.0263
-
-
 Homo sapiens kazinol B
0.0276
-
-
 Homo sapiens Brossoflurenone A
0.0333
-
-
 Homo sapiens Brossoflurenone B
0.0757
-
-
 Homo sapiens 3'-(3-methylbut-2-enyl)-3',4',7-trihydroxyflavane