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Literature summary for 3.2.1.20 extracted from

  • Arcelli, A.; Balducci, D.; Porzi, G.; Sandri, M.
    Chiral piperazine-2,5-dione derivatives as effective alpha-glucosidase inhibitors. Part 4 (2010), Chem. Biodivers., 7, 225-228.
    View publication on PubMed
Search for more literature for 3.2.1.20

Application

Application Comment Organism
medicine potential target for antidiabetic therapy Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
(1R,5R)-3-methylidene-6,8-bis[(1S)-1-phenylethyl]-6,8-diazabicyclo[3.2.2]nonane-7,9-dione
-
 Saccharomyces cerevisiae
(1R,5R)-3-methylidene-6,8-diazabicyclo[3.2.2]nonane-7,9-dione
-
 Saccharomyces cerevisiae
(1S,5S)-3-methylidene-6,8-bis[(1S)-1-phenylethyl]-6,8-diazabicyclo[3.2.2]nonane-7,9-dione
-
 Saccharomyces cerevisiae
(1S,6S)-7,9-bis[(1S)-1-phenylethyl]-7,9-diazabicyclo[4.2.2]decane-8,10-dione
-
 Saccharomyces cerevisiae
(2S,5S)-2-benzyl-3,11-bis[(1S)-1-phenylethyl]-2,3,5,6-tetrahydro-5,2-(epiminomethano)-3-benzazocine-4,12(1H)-dione
-
 Saccharomyces cerevisiae
(2S,5S)-2-methyl-3,11-bis[(1S)-1-phenylethyl]-2,3,5,6-tetrahydro-5,2-(epiminomethano)-3-benzazocine-4,12(1H)-dione
-
 Saccharomyces cerevisiae
(2S,5S)-3,11-bis[(1S)-1-phenylethyl]-2,3,5,6-tetrahydro-5,2-(epiminomethano)-3-benzazocine-4,12(1H)-dione
-
 Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Synonyms

Synonyms Comment Organism
alpha-glucosidase
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.85
-
 assay at Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 (1S,6S)-7,9-bis[(1S)-1-phenylethyl]-7,9-diazabicyclo[4.2.2]decane-8,10-dione value above 0.2 mM Saccharomyces cerevisiae
0.005
-
 (2S,5S)-2-benzyl-3,11-bis[(1S)-1-phenylethyl]-2,3,5,6-tetrahydro-5,2-(epiminomethano)-3-benzazocine-4,12(1H)-dione
-
 Saccharomyces cerevisiae
0.015
-
 (2S,5S)-2-methyl-3,11-bis[(1S)-1-phenylethyl]-2,3,5,6-tetrahydro-5,2-(epiminomethano)-3-benzazocine-4,12(1H)-dione
-
 Saccharomyces cerevisiae
0.019
-
 (1S,5S)-3-methylidene-6,8-bis[(1S)-1-phenylethyl]-6,8-diazabicyclo[3.2.2]nonane-7,9-dione
-
 Saccharomyces cerevisiae
0.022
-
 (2S,5S)-3,11-bis[(1S)-1-phenylethyl]-2,3,5,6-tetrahydro-5,2-(epiminomethano)-3-benzazocine-4,12(1H)-dione
-
 Saccharomyces cerevisiae
0.13
-
 (1R,5R)-3-methylidene-6,8-diazabicyclo[3.2.2]nonane-7,9-dione
-
 Saccharomyces cerevisiae
0.27
-
 (1R,5R)-3-methylidene-6,8-bis[(1S)-1-phenylethyl]-6,8-diazabicyclo[3.2.2]nonane-7,9-dione
-
 Saccharomyces cerevisiae