Literature summary for 3.2.1.20 extracted from

Park, H.; Hwang, K.Y.; Kim, Y.H.; Oh, K.H.; Lee, J.Y.; Kim, K.
Discovery and biological evaluation of novel alpha-glucosidase inhibitors with in vivo antidiabetic effect (2008), Bioorg. Med. Chem. Lett., 18, 3711-3715.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2E)-3-[(3-fluorophenyl)amino]-2-[4-(2-oxo-2H-chromen-3-yl)-1,3-thiazol-2-yl]prop-2-enenitrile	75.2% inhibition at 50 microM	Saccharomyces cerevisiae
(5E)-1-(3-chloro-4-methoxyphenyl)-5-([1-[2-(3-methylphenoxy)ethyl]-1H-pyrrol-2-yl]methylidene)pyrimidine-2,4,6(1H,3H,5H)-trione	88.7% inhibition at 50 microM	Saccharomyces cerevisiae
(5E)-1-(4-ethylphenyl)-5-([1-[2-(3-methylphenoxy)ethyl]-1H-pyrrol-2-yl]methylidene)pyrimidine-2,4,6(1H,3H,5H)-trione	86.0% inhibition at 50 microM	Saccharomyces cerevisiae
acarbose	88.1% inhibition at 50 microM	Saccharomyces cerevisiae
additional information	inhibitors with in vivo antidiabetic effect, serum glucose levels after single oral administration of various compounds to STZ diabetic rats decrease	Saccharomyces cerevisiae
N-(4-methylphenyl)-6-[(quinolin-8-yloxy)methyl]-1,3,5-triazine-2,4-diamine	78.9% inhibition at 50 microM	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
p-nitrophenyl alpha-D-glucopyranoside + H2O	-	Saccharomyces cerevisiae	? + p-nitrophenol + alpha-D-glucopyranose	-	?

Synonyms

Synonyms	Comment	Organism
alpha-glucosidase	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)