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Literature summary for 3.2.1.20 extracted from

  • Liu, Y.; Ke, Z.; Cui, J.; Chen, W.H.; Ma, L.; Wang, B.
    Synthesis, inhibitory activities, and QSAR study of xanthone derivatives as alpha-glucosidase inhibitors (2008), Bioorg. Med. Chem., 16, 7185-7192.
    View publication on PubMed
Search for more literature for 3.2.1.20

Inhibitors

Inhibitors Comment Organism Structure
1,3-dihydroxy-2-nitro-12H-benzo[b]xanthen-12-one highest inhibitory activity Saccharomyces cerevisiae
1,3-dihydroxy-4-nitro-9H-xanthen-9-one lowest inhibitory activity Saccharomyces cerevisiae
2-amino-1,3-dihydroxy-12H-benzo[b]xanthen-12-one
-
 Saccharomyces cerevisiae
3-(3-bromopropoxy)-1-hydroxy-12H-benzo[b]xanthen-12-one
-
 Saccharomyces cerevisiae
3-(3-bromopropoxy)-1-hydroxy-9H-xanthen-9-one
-
 Saccharomyces cerevisiae
4-amino-1,3-dihydroxy-12H-benzo[b]xanthen-12-one
-
 Saccharomyces cerevisiae
4-amino-1,3-dihydroxy-9H-xanthen-9-one
-
 Saccharomyces cerevisiae
6-hydroxy-2,3-dihydro-1H,7H-benzo[b]pyrano[3,2-h]xanthen-7-one
-
 Saccharomyces cerevisiae
6-hydroxy-2,3-dihydro-1H-pyrano[2,3-c]xanthen-7-one
-
 Saccharomyces cerevisiae
additional information xanthones and their derivatives exhibit strong inhibitory activities toward alpha-glucosidase Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Synonyms

Synonyms Comment Organism
alpha-glucosidase
-
 Saccharomyces cerevisiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0059
-
 highest inhibitory activity Saccharomyces cerevisiae 1,3-dihydroxy-2-nitro-12H-benzo[b]xanthen-12-one
0.0063
-
-
 Saccharomyces cerevisiae 2-amino-1,3-dihydroxy-12H-benzo[b]xanthen-12-one
0.0083
-
-
 Saccharomyces cerevisiae 4-amino-1,3-dihydroxy-12H-benzo[b]xanthen-12-one
0.0297
-
-
 Saccharomyces cerevisiae 3-(3-bromopropoxy)-1-hydroxy-12H-benzo[b]xanthen-12-one
0.0673
-
-
 Saccharomyces cerevisiae 6-hydroxy-2,3-dihydro-1H,7H-benzo[b]pyrano[3,2-h]xanthen-7-one
0.1023
-
-
 Saccharomyces cerevisiae 4-amino-1,3-dihydroxy-9H-xanthen-9-one
0.1466
-
-
 Saccharomyces cerevisiae 3-(3-bromopropoxy)-1-hydroxy-9H-xanthen-9-one
0.1981
-
-
 Saccharomyces cerevisiae 6-hydroxy-2,3-dihydro-1H-pyrano[2,3-c]xanthen-7-one
0.2352
-
 lowest inhibitory activity Saccharomyces cerevisiae 1,3-dihydroxy-4-nitro-9H-xanthen-9-one