Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.191 extracted from

  • Li, J.; Li, R.; Li, N.; Zheng, F.; Dai, Y.; Ge, Y.; Yue, H.; Yu, S.
    Mechanism of antidiabetic and synergistic effects of ginseng polysaccharide and ginsenoside Rb1 on diabetic rat model (2018), J. Pharm. Biomed. Anal., 158, 451-460 .
    View publication on PubMed
Search for more literature for 3.2.1.191

Inhibitors

Inhibitors Comment Organism Structure
Ginseng polysaccharides GP, when a high dose of GP is fed to diabetic rats for 15 days, the formation of intermediates, including gypenoside XVII and gypenoside LXXV is inhibited, and only one pathway (Rb1-> Rd -> F2 -> CK) is identified uncultured bacterium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information uncultured bacterium during transformation of Rb1 by diabetic rat intestinal microflora, five transformed products, including ginsenoside Rd, F2, CK, gypenoside XVII (G-XVII), and LXXV (G-LXXV), as well as three transformation pathways, are identified ?
-
 ?

Organism

Organism UniProt Comment Textmining
uncultured bacterium
-
 from diabetic rat intestinal microflora via fresh feces
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl-beta-D-glucopyranoside + H2O
-
 uncultured bacterium 4-nitrophenol + D-glucopyranose
-
 ?
ginsenoside F2 + H2O
-
 uncultured bacterium ginsenoside C-K + D-glucopyranose
-
 ?
ginsenoside Rb1 + H2O cf. EC 3.2.1.192 or EC 3.2.1.195 uncultured bacterium ginsenoside Rd + D-glucopyranose
-
 ?
ginsenoside Rb1 + H2O
-
 uncultured bacterium gypenoside XVII + D-glucopyranose
-
 ?
ginsenoside Rd + H2O
-
 uncultured bacterium ginsenoside F2 + D-glucopyranose
-
 ?
gypenoside LXXV + H2O G-LXXV uncultured bacterium ginsenoside C-K + D-glucopyranose
-
 ?
gypenoside XVII + H2O G-XVII uncultured bacterium gypenoside LXXV + D-glucose
-
 ?
gypenoside XVII + H2O cf. EC 3.2.1.193 uncultured bacterium ginsenoside F2 + D-glucopyranose
-
 ?
additional information during transformation of Rb1 by diabetic rat intestinal microflora, five transformed products, including ginsenoside Rd, F2, CK, gypenoside XVII (G-XVII), and LXXV (G-LXXV), as well as three transformation pathways, are identified uncultured bacterium ?
-
 ?
additional information when a high dose of Ginseng polysaccharides is fed to diabetic rats for 15 days, the formation of intermediates, including gypenoside XVII and gypenoside LXXV is inhibited, and only one pathway (Rb1-> Rd -> F2 -> CK) is identified, cf. EC 3.2.1.192 or EC 3.2.1.195. Mass spectrometric identification of substrates and products, overview uncultured bacterium ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at uncultured bacterium

General Information

General Information Comment Organism
metabolism pathways of ginsenoside Rb1 biotransformation in diabetic rat intestinal microflora, overview. The first is Rb1 -> Rd -> F2 -> CK. The second pathway is Rb1 -> G-XVII -> G-LXXV -> CK. The third pathway is Rb1 -> G-XVII -> F2 -> CK. Ginseng polysaccharides restore the dysbiosis of intestinal flora in diabetic rats uncultured bacterium