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Literature summary for 3.2.1.18 extracted from

  • Minami, A.; Ishii, A.; Shimba, S.; Kano, T.; Fujioka, E.; Sai, S.; Oshio, N.; Ishibashi, S.; Takahashi, T.; Kurebayashi, Y.; Kanazawa, H.; Yuki, N.; Otsubo, T.; Ikeda, K.; Suzuki, T.
    Down-regulation of glutamate release from hippocampal neurons by sialidase (2018), J. Biochem., 163, 273-280 .
    View publication on PubMed
Search for more literature for 3.2.1.18

Inhibitors

Inhibitors Comment Organism Structure
2,3-dehydro-2-deoxy-N-glycolylneuraminic acid
-
 Rattus norvegicus
2-deoxy-2,3-didehydro-D-N-acetylneuraminic acid
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ganglioside GQ1b + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ganglioside GQ1b + H2O
-
 Rattus norvegicus ?
-
 ?

Expression

Organism Comment Expression
Rattus norvegicus enzyme activity is rapidly increased in response to neural excitation up

General Information

General Information Comment Organism
physiological function the enzyme is essential for hippocampal memory and synaptic plasticity. The enzyme down-regulates glutamate release from hippocampal neurons via Ca2+ signalling modulation Rattus norvegicus