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Literature summary for 3.2.1.18 extracted from

  • Kim, J.H.; Ryu, Y.B.; Lee, W.S.; Kim, Y.H.
    Neuraminidase inhibitory activities of quaternary isoquinoline alkaloids from Corydalis turtschaninovii rhizome (2014), Bioorg. Med. Chem., 22, 6047-6052.
    View publication on PubMed
Search for more literature for 3.2.1.18

Inhibitors

Inhibitors Comment Organism Structure
Berberine reversible non-competitive inhibition Clostridium perfringens
coptisine
-
 Clostridium perfringens
curcumin
-
 Clostridium perfringens
dehydrocorybulbine
-
 Clostridium perfringens
glaucine
-
 Clostridium perfringens
Jatrorrhizine
-
 Clostridium perfringens
additional information a 95% (v/v) ethanol extract of Corydalis turtschaninovii rhizome shows neuraminidase inhibitory activity (68% at 0.03 mg/ml); not inhibited by corydaline and tetrahydrocoptisine Clostridium perfringens
palmatine reversible non-competitive inhibition Clostridium perfringens
pseudocoptisine
-
 Clostridium perfringens
pseudodehydrocorydaline
-
 Clostridium perfringens
tetrahydrocoptisine
-
 Clostridium perfringens

Organism

Organism UniProt Comment Textmining
Clostridium perfringens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O
-
 Clostridium perfringens 4-methylumbelliferone + N-acetylneuraminic acid
-
 ?

Synonyms

Synonyms Comment Organism
neuraminidase
-
 Clostridium perfringens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.006
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens curcumin
0.0128
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens palmatine
0.0135
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens Berberine
0.0251
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens coptisine
0.0326
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens pseudodehydrocorydaline
0.037
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens Jatrorrhizine
0.0413
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens dehydrocorybulbine
0.0652
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens pseudocoptisine
0.0969
-
 in 50 mM sodium acetate buffer (pH 5.0), at 22°C Clostridium perfringens glaucine

General Information

General Information Comment Organism
physiological function the enzyme plays a pivotal role in bacterial proliferation Clostridium perfringens