Protein Variants | Comment | Organism |
---|---|---|
Q136K | the neuraminidase mutation has no effect on oseltamivir susceptibility but causes approximately a 300fold and a 70fold reduction in zanamivir and peramivir susceptibility, respectively. The mutant strain displays greater viral fitness than the wild-type virus in MDCK cells but equivalent infectivity and transmissibility in a ferret model | influenza A virus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
oseltamivir | - |
influenza A virus | |
peramivir | - |
influenza A virus | |
zanamivir | - |
influenza A virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
influenza A virus | Q07599 | H1N1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O | - |
influenza A virus | 4-methylumbelliferone + N-acetylneuraminic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
neuraminidase | - |
influenza A virus |