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Literature summary for 3.2.1.18 extracted from

  • Ryu, Y.B.; Curtis-Long, M.J.; Lee, J.W.; Kim, J.H.; Kim, J.Y.; Kang, K.Y.; Lee, W.S.; Park, K.H.
    Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata (2009), Bioorg. Med. Chem., 17, 2744-2750.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,3,6,7-tetrahydroxy-2-(3-methylbut-2-enyl)-8-(2-methylbut-3-en-2-yl)-9H-xanthen-9-one competitive Clostridium perfringens
cudratricusxanthone competitive Clostridium perfringens
cudraxanthone L competitive Clostridium perfringens
cudraxanthone M competitive Clostridium perfringens
macluraxanthone competitive Clostridium perfringens

Organism

Organism UniProt Comment Textmining
Clostridium perfringens Q59310 commercial product
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid + H2O
-
Clostridium perfringens 4-methylumbelliferol + alpha-D-N-acetylneuraminic acid
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000058
-
1,3,6,7-tetrahydroxy-2-(3-methylbut-2-enyl)-8-(2-methylbut-3-en-2-yl)-9H-xanthen-9-one pH 5.0, 37°C Clostridium perfringens
0.000098
-
cudraxanthone M pH 5.0, 37°C Clostridium perfringens
0.000103
-
macluraxanthone pH 5.0, 37°C Clostridium perfringens
0.000136
-
cudratricusxanthone pH 5.0, 37°C Clostridium perfringens
0.000138
-
cudraxanthone L pH 5.0, 37°C Clostridium perfringens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00008
-
pH 5.0, 37°C Clostridium perfringens 1,3,6,7-tetrahydroxy-2-(3-methylbut-2-enyl)-8-(2-methylbut-3-en-2-yl)-9H-xanthen-9-one
0.000186
-
pH 5.0, 37°C Clostridium perfringens cudraxanthone M
0.000186
-
pH 5.0, 37°C Clostridium perfringens macluraxanthone
0.000228
-
pH 5.0, 37°C Clostridium perfringens cudraxanthone L
0.000245
-
pH 5.0, 37°C Clostridium perfringens cudratricusxanthone