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Literature summary for 3.2.1.18 extracted from

  • Nan, X.; Carubelli, I.; Stamatos, N.M.
    Sialidase expression in activated human T lymphocytes influences production of IFN-gamma (2007), J. Leukoc. Biol., 81, 284-296.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q99519
-
-
Homo sapiens Q9UQ49
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-lymphocyte only lysosomal Neu1 and plasma membrane-associated Neu3 are detected in freshly isolated and activated human T lymphocytes. Activation of lymphocytes by exposure to anti-CD3 and anti-CD28 IgG results in a ninefold increase in Neu1-specific activity after growth of cells in culture for 5 days. The increase in Neu1 enzyme activity correlates with increased synthesis of Neu1-specific mRNA. Neu1 is present on the surface of freshly isolated and activated CD4 and CD8 T lymphocytes. Cell surface Neu1 is tightly associated with a subunit of protective protein/cathepsin A. Sialidase activity in activated T lymphocytes contributes to the hyposialylation of specific cell surface glycoconjugates and to the production of IFN-gamma Homo sapiens
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T-lymphocyte only lysosomal Neu1 and plasma membrane-associated Neu3 are detected in freshly isolated and activated human T lymphocytes. Activity of Neu3 changes minimally in activated lymphocytes. Sialidase activity in activated T lymphocytes contributes to the hyposialylation of specific cell surface glycoconjugates and to the production of IFN-gamma Homo sapiens
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Synonyms

Synonyms Comment Organism
NEU1
-
Homo sapiens
Neu3
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Homo sapiens