Literature summary for 3.2.1.18 extracted from

Richard, M.; Deleage, C.; Barthelemy, M.; Lin, Y.P.; Hay, A.; Lina, B.; Ferraris, O.
Impact of influenza A virus neuraminidase mutations on the stability, activity, and sensibility of the neuraminidase to neuraminidase inhibitors (2008), J. Clin. Virol., 41, 20-24.

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Protein Variants

Protein Variants	Comment	Organism
D198N	neuraminidase activity is 10% of wild-type value. IC50 for zanamivir is 5fold higher than wild-type value. IC50 for oseltamivir is 5.5fold higher than wild-type value	influenza A virus
E119D	neuraminidase activity is 1.3% of wild-type value	influenza A virus
E227G	mutation results in an impairment of growth of the concerned virus	influenza A virus
E245G	neuraminidase activity is 73% of wild-type value. IC50 for zanamivir is 2.9fold higher than wild-type value. IC50 for oseltamivir is 2.3fold higher than wild-type value	influenza A virus
E277G	mutation results in an impairment of growth of the concerned virus	influenza A virus
H274Y	neuraminidase activity is 104% of wild-type value. IC50 for zanamivir is 3.2fold higher than wild-type value. IC50 for oseltamivir is 9.4fold higher than wild-type value	influenza A virus
I222L	neuraminidase activity is 82% of wild-type value. IC50 for zanamivir is 5.1fold higher than wild-type value. IC50 for oseltamivir is 18fold higher than wild-type value	influenza A virus
N294D	neuraminidase activity is 74% of wild-type value. IC50 for zanamivir is 2.4fold higher than wild-type value. IC50 for oseltamivir is 2.3fold higher than wild-type value	influenza A virus
R156K	neuraminidase activity is 71% of wild-type value	influenza A virus
S179A	mutation results in an impairment of growth of the concerned virus	influenza A virus
W178L	mutation results in an impairment of growth of the concerned virus	influenza A virus

Inhibitors

Inhibitors	Comment	Organism	Structure
oseltamivir	-	influenza A virus
zanamivir	-	influenza A virus

Organism

Organism	UniProt	Comment	Textmining
influenza A virus	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00099	-	wild-type enzyme	influenza A virus	zanamivir
0.00103	-	mutant enzyme R156K	influenza A virus	zanamivir
0.00242	-	mutant enzyme N294D	influenza A virus	zanamivir
0.00287	-	mutant enzyme E425G	influenza A virus	zanamivir
0.00312	-	mutant enzyme H274Y	influenza A virus	zanamivir
0.00498	-	mutant enzyme D198N	influenza A virus	zanamivir
0.00502	-	mutant enzyme I222L	influenza A virus	zanamivir

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Release 2023.1 (January 2023)