Literature summary for 3.2.1.18 extracted from

Chavas, L.M.; Tringali, C.; Fusi, P.; Venerando, B.; Tettamanti, G.; Kato, R.; Monti, E.; Wakatsuki, S.
Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition (2005), J. Biol. Chem., 280, 469-475.

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop method, high resolution X-ray structures of human sialidase Neu2, in its apo form and in complex with the inhibitor 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. The structure shows the canonical six-blade beta-propeller observed in viral and bacterial sialidases with its active site in a shallow crevice. In the complex structure, the inhibitor lies in the catalytic crevice surrounded by ten amino acids	Homo sapiens

Crystallization (Comment)

Organism

hanging drop method, high resolution X-ray structures of human sialidase Neu2, in its apo form and in complex with the inhibitor 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. The structure shows the canonical six-blade beta-propeller observed in viral and bacterial sialidases with its active site in a shallow crevice. In the complex structure, the inhibitor lies in the catalytic crevice surrounded by ten amino acids

Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y3R4	-	-

Synonyms

Synonyms	Comment	Organism
sialidase Neu2	-	Homo sapiens

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Release 2023.1 (January 2023)