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Literature summary for 3.2.1.18 extracted from
- The plasma membrane-associated sialidase MmNEU3 modifies the ganglioside pattern of adjacent cells supporting its involvement in cell-to-cell interactions (2004), J. Biol. Chem., 279, 16989-16995.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| C-terminally HA-tagged enzyme, transient functional overexpression in COS-7 cells, location at the cell surface in the plasma membrane | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | associated, cell-surface location | Mus musculus | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ganglioside GD1a + H2O | Mus musculus | in transfected cells, mainly via cell-cell-interaction | ganglioside GM1 + sialic acid | - |
? |  |
| ganglioside GM3 + H2O | Mus musculus | in transfected cells, mainly via cell-cell-interaction | sialic acid + ? | - |
? | |
| additional information | Mus musculus | the enzyme modifies the ganglioside pattern of adjacent cells, involved in cell-cell-interaction | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O | - |
Mus musculus | 4-methylumbelliferol + alpha-D-N-acetylneuraminic acid | - |
? | |
| ganglioside GD1a + H2O | in transfected cells, mainly via cell-cell-interaction | Mus musculus | ganglioside GM1 + sialic acid | - |
? | |
| ganglioside GD1a + H2O | - |
Mus musculus | sialic acid + ? | - |
? | |
| ganglioside GM3 + H2O | - |
Mus musculus | sialic acid + ? | - |
? | |
| ganglioside GM3 + H2O | in transfected cells, mainly via cell-cell-interaction | Mus musculus | sialic acid + ? | - |
? | |
| additional information | the enzyme modifies the ganglioside pattern of adjacent cells, involved in cell-cell-interaction | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MmNEU3 | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 3.8 | - |
assay at | Mus musculus |
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Release 2023.1 (January 2023)
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