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Literature summary for 3.2.1.169 extracted from

  • He, Y.; Martinez-Fleites, C.; Bubb, A.; Gloster, T.M.; Davies, G.J.
    Structural insight into the mechanism of streptozotocin inhibition of O-GlcNAcase (2009), Carbohydr. Res., 344, 627-631.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
the N-terminal His6-tagged recombinant BtGH84 protein is expressed Bacteroides thetaiotaomicron

Crystallization (Commentary)

Crystallization (Comment) Organism
X-ray crystallography Bacteroides thetaiotaomicron

Inhibitors

Inhibitors Comment Organism Structure
streptozotocin binds in the enzyme active site in its intact form, without the formation of a covalent adduct, weak inhibitor Bacteroides thetaiotaomicron

Organism

Organism UniProt Comment Textmining
Bacteroides thetaiotaomicron Q89ZI2
-
-

Purification (Commentary)

Purification (Comment) Organism
the N-terminal His6-tagged recombinant BtGH84 protein is purified Bacteroides thetaiotaomicron

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl N-acetyl-beta-D-glucosaminide + H2O
-
Bacteroides thetaiotaomicron 4-nitrophenol + N-acetyl-beta-D-glucosamine
-
?

Synonyms

Synonyms Comment Organism
BtGH84 a bacterial homolog to the human enzyme Bacteroides thetaiotaomicron
O-GlcNAcase
-
Bacteroides thetaiotaomicron