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Literature summary for 3.2.1.169 extracted from

  • Ngoh, G.A.; Facundo, H.T.; Hamid, T.; Dillmann, W.; Zachara, N.E.; Jones, S.P.
    Unique hexosaminidase reduces metabolic survival signal and sensitizes cardiac myocytes to hypoxia/reoxygenation injury (2009), Circ. Res., 104, 41-49.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate PUGNAc Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiac myocyte
-
 Rattus norvegicus
-
cardiac myocyte NRCM Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
hexosaminidase
-
 Rattus norvegicus
O-GlcNAcase
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus neonatal rat cardiac myocytes (NRCM) are treated with 60 nmol/l O-GlcNAcase RNAi or Scr RNAi for 72 hours to knockdown O-GlcNAcase expression. Knockdown of O-GlcNAcase reduces posthypoxic cardiac myocyte injury down