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Literature summary for 3.2.1.147 extracted from

  • Zhao, Y.; Wang, J.; Liu, Y.; Miao, H.; Cai, C.; Shao, Z.; Guo, R.; Sun, B.; Jia, C.; Zhang, L.; Gigolashvili, T.; Wang, Q.
    Classic myrosinase-dependent degradation of indole glucosinolate attenuates fumonisin B1-induced programmed cell death in Arabidopsis (2015), Plant J., 81, 920-933 .
    View publication on PubMed
Search for more literature for 3.2.1.147

Protein Variants

Protein Variants Comment Organism
additional information mutant pen2-2, the mutant of atypical myrosinase PEN2 with highly reduced enzyme activity, shows fewer lesions compared with myrosinase double mutant tgg1 tgg2 and exhibits a symptoms similar to the wild-type in response to mycotoxin fumonisin B1 (FB1), indicating that deficiency of TGG instead of PEN2 renders plants significantly more sensitive to FB1 Arabidopsis thaliana
additional information the costructed tgg1 tgg2 double mutant, which has greatly reduced TGG activity, shows more severe lesion formation and cell death symptoms than Col-0. Mutant pen2-2, the mutant of atypical myrosinase PEN2 with highly reduced enzyme activity, shows fewer lesions compared with myrosinase double mutant tgg1 tgg2 and exhibits a symptoms similar to the wild-type in response to mycotoxin fumonisin B1 (FB1), indicating that deficiency of TGG instead of PEN2 renders plants significantly more sensitive to FB1 Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
 Arabidopsis thaliana 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-methoxyindol-3-ylmethyl-glucosinolate + H2O Arabidopsis thaliana
-
 1-methoxyindol-3-ylmethyl isothiocyanate + D-glucose
-
 ?
1-methoxyindol-3-ylmethyl-glucosinolate + H2O Arabidopsis thaliana Col-0
-
 1-methoxyindol-3-ylmethyl isothiocyanate + D-glucose
-
 ?
4-methoxyindol-3-ylmethyl-glucosinolate + H2O Arabidopsis thaliana
-
 4-methoxyindol-3-ylmethyl isothiocyanate + D-glucose
-
 ?
4-methoxyindol-3-ylmethyl-glucosinolate + H2O Arabidopsis thaliana Col-0
-
 4-methoxyindol-3-ylmethyl isothiocyanate + D-glucose
-
 ?
indol-3-ylmethyl glucosinolate + H2O Arabidopsis thaliana
-
 indol-3-ylmethyl isothiocyanate + D-glucose
-
 ?
indol-3-ylmethyl glucosinolate + H2O Arabidopsis thaliana Col-0
-
 indol-3-ylmethyl isothiocyanate + D-glucose
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana O64883
-
-
Arabidopsis thaliana P37702
-
-
Arabidopsis thaliana Col-0 O64883
-
-
Arabidopsis thaliana Col-0 P37702
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-methoxyindol-3-ylmethyl-glucosinolate + H2O
-
 Arabidopsis thaliana 1-methoxyindol-3-ylmethyl isothiocyanate + D-glucose
-
 ?
1-methoxyindol-3-ylmethyl-glucosinolate + H2O
-
 Arabidopsis thaliana Col-0 1-methoxyindol-3-ylmethyl isothiocyanate + D-glucose
-
 ?
4-methoxyindol-3-ylmethyl-glucosinolate + H2O
-
 Arabidopsis thaliana 4-methoxyindol-3-ylmethyl isothiocyanate + D-glucose
-
 ?
4-methoxyindol-3-ylmethyl-glucosinolate + H2O
-
 Arabidopsis thaliana Col-0 4-methoxyindol-3-ylmethyl isothiocyanate + D-glucose
-
 ?
indol-3-ylmethyl glucosinolate + H2O
-
 Arabidopsis thaliana indol-3-ylmethyl isothiocyanate + D-glucose
-
 ?
indol-3-ylmethyl glucosinolate + H2O
-
 Arabidopsis thaliana Col-0 indol-3-ylmethyl isothiocyanate + D-glucose
-
 ?
additional information the enzyme is active with indole and aliphatic glucosinolates Arabidopsis thaliana ?
-
 ?
additional information the enzyme is active with indole and aliphatic glucosinolates Arabidopsis thaliana Col-0 ?
-
 ?

Synonyms

Synonyms Comment Organism
AtBGLU38
-
 Arabidopsis thaliana
atypical myrosinase
-
 Arabidopsis thaliana
beta-glucosidase 26, peroxisomal UniProt Arabidopsis thaliana
beta-glucosidase 38
-
 Arabidopsis thaliana
BGLU26
-
 Arabidopsis thaliana
myrosinase
-
 Arabidopsis thaliana
PEN2
-
 Arabidopsis thaliana
sinigrinase 1
-
 Arabidopsis thaliana
TGG1
-
 Arabidopsis thaliana
thioglucosidase 1
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction the classic myrosinase beta-thioglucoside glucohydrolase (TGG)-deficient double mutant tgg1 tgg2, rather than atypical myrosinase-deficient mutant pen2-2, is more sensitive to the mycotoxin fumonisin B1 (FB1) than wild-type Col-0, and the elevated expression of isozyme TGG1, but not of PEN2, correlates with the decrease in indole glucosinolate (IGS), TGG-dependent IGS hydrolysis is involved in FB1-induced programmed cell death (PCD) Arabidopsis thaliana
metabolism metabolism of tryptophan-derived indole glucosinolate (IGS), camalexin and indol-3-acetic acid (IAA) as well as methioninederived aliphatic glucosinolate (AGS) in Arabidopsis thaliana involving the myrosinase enzymes TGG1 and PEN2, overview Arabidopsis thaliana
metabolism metabolism of tryptophan-derived indole glucosinolate (IGS), camalexin and indole-3-acetic acid (IAA) as well as methioninederived aliphatic glucosinolate (AGS) in Arabidopsis thaliana involving the myrosinase enzymes TGG1 and PEN2, overview. FB1-induced biosynthesis of glucosinolates. FB1 treatment triggers not only biosynthesis but also hydrolysis of IGS Arabidopsis thaliana
additional information the cyp79B2 cyp79B3 mutant, which has a greatly reduced level of indole glucosinolates, is more sensitive to mycotoxin fumonisin B1 (FB1) Arabidopsis thaliana
physiological function classical TGG-dependent hydrolysis of indole glucosinolate (IGS) restricts FB1-induced programmed cell death (PCD). Mycotoxin fumonisin B1 (FB1) causes the accumulation of reactive oxygen species (ROS) which then leads to PCD in Arabidopsis thaliana. FB1-induced biosynthesis of glucosinolates. FB1 treatment triggers not only biosynthesis but also hydrolysis of IGS Arabidopsis thaliana