Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(3-chloro-4-(naphthalen-2-yloxy)phenylcarbamoyl)benzoic acid | - |
Homo sapiens | |
3,5-dichloro-2-hydroxy-N-(3-methyl-4-(naphthalen-2-yloxy)phenyl)benzamide | - |
Homo sapiens | |
3,5-dichloro-2-hydroxy-N-(4-(naphthalen-2-yloxy)-3-(trifluoromethyl)phenyl)benzamide | - |
Homo sapiens | |
3,5-dichloro-2-hydroxy-N-(4-(naphthalen-2-yloxy)phenyl)benzamide | - |
Homo sapiens | |
3,5-dichloro-2-hydroxy-N-m-tolylbenzamide | between 10% and 30% inhibition at 0.5 mM | Homo sapiens | |
3,5-dichloro-2-hydroxy-N-o-tolylbenzamide | between 10% and 30% inhibition at 0.5 mM | Homo sapiens | |
3,5-dichloro-2-hydroxy-N-p-tolylbenzamide | between 10% and 30% inhibition at 0.5 mM | Homo sapiens | |
3,5-dichloro-N-(2-chlorophenyl)-2-hydroxybenzamide | between 10% and 30% inhibition at 0.5 mM | Homo sapiens | |
3,5-dichloro-N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxy-N-methylbenzamide | - |
Homo sapiens | |
3,5-dichloro-N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxybenzamide | - |
Homo sapiens | |
3,5-dichloro-N-(3-chloro-4-(p-tolyloxy)phenyl)-2-hydroxybenzamide | - |
Homo sapiens | |
3,5-dichloro-N-(3-chloro-4-phenoxyphenyl)-2-hydroxybenzamide | - |
Homo sapiens | |
3,5-dichloro-N-(3-chlorophenyl)-2-hydroxybenzamide | - |
Homo sapiens | |
3,5-dichloro-N-(3-fluoro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxybenzamide | - |
Homo sapiens | |
3,5-dichloro-N-(4-chlorophenyl)-2-hydroxybenzamide | - |
Homo sapiens | |
3,5-dichloro-N-[3-chloro-4-(naphthalen-2-yloxy)phenyl]-2-hydroxybenzamide | - |
Homo sapiens | |
3-bromo-5-chloro-N-[5-chloro-2-[(1-chloronaphthalen-2-yl)oxy]phenyl]-2-hydroxybenzamide | - |
Homo sapiens | |
3-bromo-N-[2-[2-bromo-6-methyl-3-(propan-2-yl)phenoxy]-5-chlorophenyl]-5-chloro-2-hydroxybenzamide | - |
Homo sapiens | |
3-chloro-N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxybenzamide | - |
Homo sapiens | |
5-chloro-N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxybenzamide | - |
Homo sapiens | |
ADP-(hydroxymethyl)pyrrolidinediol | - |
Homo sapiens | |
ethacridine | - |
Homo sapiens | |
additional information | not inhibited by benzamide, 3,5-dichloro-N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)benzamide, 3,5-dichloro-N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-methoxybenzamide, 2,4-dichloro-6-((3-chloro-4-(naphthalen-2-yloxy)phenylimino)methyl)phenol, 2,4-dichloro-6-((3-chloro-4-(naphthalen-2-yloxy)phenylamino)methyl)phenol, 3,5-dichloro-2-hydroxybenzamide, 3,5-dichloro-N-(3-chloro-4-hydroxyphenyl)-2-hydroxybenzamide, and 3,5-dichloro-2-hydroxy-N-benzamide | Homo sapiens | |
N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxybenzamide | - |
Homo sapiens | |
N-bis-(3-phenylpropyl)-9-oxofluorene-2,7-diamide | GPI 16552 | Homo sapiens | |
N-[4-[(3-bromonaphthalen-2-yl)oxy]-3-chlorophenyl]-3,5-dichloro-2-hydroxybenzamide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
poly(ADP-ribose) + H2O | - |
Homo sapiens | ADP-ribose oligomer + ADP-ribose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PARG | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00012 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | ADP-(hydroxymethyl)pyrrolidinediol | |
0.012 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | 3,5-dichloro-N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxybenzamide | |
0.012 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | 3,5-dichloro-N-[3-chloro-4-(naphthalen-2-yloxy)phenyl]-2-hydroxybenzamide | |
0.021 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | 3,5-dichloro-2-hydroxy-N-(4-(naphthalen-2-yloxy)-3-(trifluoromethyl)phenyl)benzamide | |
0.022 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | 3-bromo-5-chloro-N-[5-chloro-2-[(1-chloronaphthalen-2-yl)oxy]phenyl]-2-hydroxybenzamide | |
0.025 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | 3,5-dichloro-2-hydroxy-N-(3-methyl-4-(naphthalen-2-yloxy)phenyl)benzamide | |
0.026 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | 3,5-dichloro-N-(3-chloro-4-(p-tolyloxy)phenyl)-2-hydroxybenzamide | |
0.026 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | 3-bromo-N-[2-[2-bromo-6-methyl-3-(propan-2-yl)phenoxy]-5-chlorophenyl]-5-chloro-2-hydroxybenzamide | |
0.027 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | 3,5-dichloro-N-(3-fluoro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxybenzamide | |
0.042 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | 3,5-dichloro-2-hydroxy-N-(4-(naphthalen-2-yloxy)phenyl)benzamide | |
0.061 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | 3-chloro-N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxybenzamide | |
0.061 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | 3,5-dichloro-N-(3-chloro-4-phenoxyphenyl)-2-hydroxybenzamide | |
0.072 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | 2-(3-chloro-4-(naphthalen-2-yloxy)phenylcarbamoyl)benzoic acid | |
0.08 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | N-[4-[(3-bromonaphthalen-2-yl)oxy]-3-chlorophenyl]-3,5-dichloro-2-hydroxybenzamide | |
0.117 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | 5-chloro-N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxybenzamide | |
0.14 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | 3,5-dichloro-N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxy-N-methylbenzamide | |
0.261 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | 3,5-dichloro-N-(3-chlorophenyl)-2-hydroxybenzamide | |
0.5 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-2-hydroxybenzamide | |
0.5 | - |
in 150 mM potassium phosphate buffer, pH 7.5, 150 mM KCl, 0.3 mg/ml bovine serum albumin, and 30 mM 2-mercaptoethanol, at 37°C | Homo sapiens | 3,5-dichloro-N-(4-chlorophenyl)-2-hydroxybenzamide |
General Information | Comment | Organism |
---|---|---|
physiological function | at higher levels of DNA damage, the coordinate activities of PARPs-1/2 and PARG can rapidly deplete the pool of cellular NAD(H), facilitating the release of mitochondrial proteins through signaling pathways that promote cell death | Homo sapiens |