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Literature summary for 3.2.1.143 extracted from

  • Burns, D.M.; Ying, W.; Kauppinen, T.M.; Zhu, K.; Swanson, R.A.
    Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase (2009), PLoS ONE, 4, e4896.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
phosphorodiamidate morpholino oligonucleotide antisense phosphorodiamidate morpholino oligonucleotide blocks exon 1 of the full length nuclear PARG 111 kDa isoform, slowing down the rate of nuclear poly(ADP-ribose) degradation, attenuating poly(ADP-ribose) polymerase-1 mediated cell death, reducing PARG expression as shown by immunostaining, upon incubation with 50 microM alcylating agent N-methyl-N'-nitro-N'-nitrosoguanidine to induce cell death blocking of nuclear PARG reduced cell condensation and cell death, no inhibitory influence on cytosol PARG Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-
nucleus
-
Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus function in cell death ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte cortical cell culture Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone-bound poly(ADP-ribose) + H2O C14-labelled poly(ADP-ribose) produced by PARP-1 (poly(ADP-ribose) polymerase) of labelled NAD+ Mus musculus ADP-ribose + ADP-ribose oligomer + ?
-
?
additional information function in cell death Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
PARG several isoforms, full length nuclear PARG is studied Mus musculus
poly(ADP-ribose) glycohydrolase
-
Mus musculus