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Literature summary for 3.2.1.143 extracted from

  • Ono, T.; Kasamatsu, A.; Oka, S.; Moss, J.
    The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases (2006), Proc. Natl. Acad. Sci. USA, 103, 16687-16691.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
D77N/D78N mutation abolishes the hydrolytic activity on O-acetyl-ADP-ribose Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for hydrolysis of O-acetyl-ADP-ribose Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 isoform ARH3
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-O-acetyl-ADP-ribose + H2O rate of hydrolysis by isoform ARH3 is 250fold that observed with isoform ARH1, isoform ARH2 is inactive with this substrate Homo sapiens ADP-ribose + acetate
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