Literature summary for 3.2.1.143 extracted from

Cuzzocrea, S.; Genovese, T.; Mazzon, E.; Crisafulli, C.; Min, W.; Di Paola, R.; Muia, C.; Li, J.H.; Esposito, E.; Bramanti, P.; Xu, W.; Massuda, E.; Zhang, J.; Wang, Z.Q.
Poly(ADP-ribose) glycohydrolase activity mediates post-traumatic inflammatory reaction after experimental spinal cord trauma (2006), J. Pharmacol. Exp. Ther., 319, 127-138.

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Application

Application	Comment	Organism
medicine	enzyme activity modulates the inflammatory response and tissue events associated with spinal cord trauma and participates in target organ damage under these conditions	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	disruption of poly(ADP-ribose) glycohydrolase gene results in significant reduction of spinal cord inflammation and tissue injury, neutrophil infiltration, cytokine production, and apoptosis upon spinal cord injury	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
N-bis-(3-phenyl-propyl)9-oxo-fluorene-2,7-diamide	i.e. GPI 16552, pharmacological inhibitor. Enzyme inhibition results in significant reduction of spinal cord inflammation and tissue injury, neutrophil infiltration, cytokine production, and apoptosis upon spinal cord injury. Additionally, inhibition significantly ameliorates the recovery of limb function	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	enzyme activity modulates the inflammatory response and tissue events associated with spinal cord trauma and participates in target organ damage under these conditions	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme activity modulates the inflammatory response and tissue events associated with spinal cord trauma and participates in target organ damage under these conditions	Mus musculus	?	-	?

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Release 2023.1 (January 2023)