Literature summary for 3.2.1.143 extracted from

Meyer, R.G.; Meyer-Ficca, M.L.; Whatcott, C.J.; Jacobson, E.L.; Jacobson, M.K.
Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity (2007), Exp. Cell Res., 313, 2920-2936.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	and mitochondrion, predominant localization of isoform hPARG60	Homo sapiens	5737	-
mitochondrion	isoform hPARG55, strictly targeted to mitochondria. Isoform hPARG may be capable of shuttling between nucleus and mitochondria	Homo sapiens	5739	-
nucleus	isoform hPARG may be capable of shuttling between nucleus and mitochondria	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	splicing variants hPARG60 and hPARG55. HPARG55 is expressed through alternative translation initiation from hPARG60 transcripts	-

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Release 2023.1 (January 2023)