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Literature summary for 3.2.1.143 extracted from

  • St-Laurent, J.F.; Gagnon, S.N.; Dequen, F.; Hardy, I.; Desnoyers, S.
    Altered DNA damage response in Caenorhabditis elegans with impaired poly(ADP-ribose) glycohydrolases genes expression (2007), DNA Repair, 6, 329-343.
    View publication on PubMed
Search for more literature for 3.2.1.143

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli as His-tagged protein Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
D253N decrease in catalytic activity Caenorhabditis elegans
D536N loss of catalytic activity Caenorhabditis elegans
E271N complete loss of catalytic activity Caenorhabditis elegans
E272N complete loss of catalytic activity Caenorhabditis elegans
E554N decrease in catalytic activity Caenorhabditis elegans
E555N loss of catalytic activity Caenorhabditis elegans
additional information enzyme knock-down by RNAi results in increased radiation sensitivity of worms Caenorhabditis elegans
Y311A almost complete loss of catalytic activity Caenorhabditis elegans
Y594A decrease in catalytic activity Caenorhabditis elegans

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Caenorhabditis elegans 5737
-
nucleus
-
 Caenorhabditis elegans 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 x * 55000, SDS-PAGE of His-tagged protein Caenorhabditis elegans
91256
-
 x * 91256, calculated for His-tagged protein, x * 138000, SDS-PAGE of His-tagged protein, enzyme behaves abnormally in SDS-PAGE Caenorhabditis elegans
138000
-
 x * 91256, calculated for His-tagged protein, x * 138000, SDS-PAGE of His-tagged protein, enzyme behaves abnormally in SDS-PAGE Caenorhabditis elegans

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans Q867X0 isoforms PME-3, expression throughout the life cycle
-
Caenorhabditis elegans Q9N5L4 isoforms PME-4, expression throughout the life cycle
-

Source Tissue

Source Tissue Comment Organism Textmining
head predominant expression in nerve cells of head and tail Caenorhabditis elegans
-
nerve predominant expression in nerve cells of head and tail Caenorhabditis elegans
-
tail predominant expression in nerve cells of head and tail Caenorhabditis elegans
-

Subunits

Subunits Comment Organism
? x * 55000, SDS-PAGE of His-tagged protein Caenorhabditis elegans
? x * 91256, calculated for His-tagged protein, x * 138000, SDS-PAGE of His-tagged protein, enzyme behaves abnormally in SDS-PAGE Caenorhabditis elegans