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Literature summary for 3.2.1.14 extracted from

  • Wu, Y.; Preston, G.; Bianco, A.E.
    Chitinase is stored and secreted from the inner body of microfilariae and has a role in exsheathment in the parasitic nematode Brugia malayi (2008), Mol. Biochem. Parasitol., 161, 55-62.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.1.14

Inhibitors

Inhibitors Comment Organism Structure
allosamidin complete inhibition at 5 nM Brugia malayi

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular chitinase is stored and secreted from the inner body of microfilariae via either the pharyngeal thread, or during transmission of the microfilariae to the vector, contained in vesicle-like structures Brugia malayi
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microfilarial stage chitinase is stored and secreted from the inner body of microfilariae Brugia malayi
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Organism

Organism UniProt Comment Textmining
Brugia malayi P29030 parasitic nematode in Onchocerca volvulus larvae
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Source Tissue

Source Tissue Comment Organism Textmining
additional information nematodes are cultured in Meriones unguiculatus, Mongolian jirds, and Aedes aegypti mosquitos as hosts of different larval stages, overview Brugia malayi
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl GlcNAcbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O
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 Brugia malayi 4-methylumbelliferone + GlcNAcbeta(1-4)GlcNAcbeta(1-4)GlcNAc
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 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
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 assay at Brugia malayi

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
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 assay at Brugia malayi