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Literature summary for 3.2.1.14 extracted from
- Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism (2009), J. Immunol., 182, 5098-5106.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in A-549 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | mutation of the chitin-cleaving domain abolishes the chitinase activity, overview | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| allosamidin | inhibits by direct blocking of the enzyme or blocking of target binding | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | acidic mammalian chitinase plays an important role in the pathogenesis of Th2-mediated diseases and antiparasite responses, it regulates epithelial cell apoptosis via a chitinolytic-independent mechanism, AMCase induces phosphorylations by Akt activation, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | - |
Homo sapiens | - |
| pulmonary epithelial cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methylumbelliferyl-D-N,N'-diacetylchito-bioside + H2O | - |
Homo sapiens | 4-methylumbelliferone + D-N,N'-diacetylchito-bioside | - |
? | |
| additional information | acidic mammalian chitinase plays an important role in the pathogenesis of Th2-mediated diseases and antiparasite responses, it regulates epithelial cell apoptosis via a chitinolytic-independent mechanism, AMCase induces phosphorylations by Akt activation, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acidic mammalian chitinase | - |
Homo sapiens |
| AMCase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.2 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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