Literature summary for 3.2.1.129 extracted from

Martin, N.T.; Wrede, C.; Niemann, J.; Brooks, J.; Schwarzer, D.; Kuehnel, F.; Gerardy-Schahn, R.
Targeting polysialic acid-abundant cancers using oncolytic adenoviruses with fibers fused to active bacteriophage borne endosialidase (2018), Biomaterials, 158, 86-94 .

Search for more literature for 3.2.1.129

Application

Application	Comment	Organism
medicine	the enzyme recognizes polysialic acid, an oncofetal antigen characteristic for high malignant tumors of neuroendocrine origin	Escherichia phage K1F

Protein Variants

Protein Variants	Comment	Organism
K410A	partially active mutant	Escherichia phage K1F
R596A/R647	inactive	Escherichia phage K1F

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
alpha-2,8-linked polysialic acid + H2O	Escherichia phage K1F	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia phage K1F	O04830	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
alpha-2,8-linked polysialic acid + H2O	-	Escherichia phage K1F	?	-	?

Synonyms

Synonyms	Comment	Organism
endoNF	-	Escherichia phage K1F
endosialidase	-	Escherichia phage K1F
endosialidaseNF	-	Escherichia phage K1F

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Release 2023.1 (January 2023)