Literature summary for 3.2.1.123 extracted from

Ji, L.; Ito, M.; Zhang, G.; Hirabayashi, Y.; Inokuchi, J.; Yamagata, T.
Effects of endoglycoceramidase or D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol on glucose uptake, glycolysis, and mitochondrial respiration in HL60 cells (1998), Arch. Biochem. Biophys., 359, 107-114.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Activator protein	activator protein II is specific for EGCase II	Rhodococcus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rhodococcus sp.	reduces glycosphingolipid levels in HL60 cells	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rhodococcus sp.	-	M-777	-

Purification (Commentary)

Purification (Comment)	Organism
EGCase II	Rhodococcus sp.

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Galbeta(1-4)Glcbeta(1-1)ceramide + H2O	i.e. lactosylceramide	Rhodococcus sp.	Galbeta(1-4)Glc + ceramide	-	?
additional information	reduces glycosphingolipid levels in HL60 cells	Rhodococcus sp.	?	-	?
NeuAcalpha(2-3)Galbeta(1-4)Glcbeta(1-1)ceramide + H2O	i.e. GM3	Rhodococcus sp.	NeuAcalpha(2-3)Galbeta(1-4)Glc + ceramide	-	?

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Release 2023.1 (January 2023)