Application | Comment | Organism |
---|---|---|
medicine | single nucleotide polymorphisms in MAN2A1 may be a genetic factor for inflammatory bowel disease | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P27046 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestinal epithelium | cells selectively express alpha-mannosidase II, with minimal expression of its isozyme, alpha-mannosidase IIx | Mus musculus | - |
intestine | epithelium | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
alpha-mannosidase II | - |
Mus musculus |
alpha-MII | - |
Mus musculus |
MAN2A1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | alpha-mannosidase II deficiency has a minimal effect on N-glycan maturation in most cell types due to the compensation by alpha-mannosidase IIx, ablation of alpha-MII impairs the maturation of N-glycans in intestinal epithelial cells. alpha-mannosidase II (DELTA intestinal epithelial cell) mice are less susceptible to dextran sulfate sodium-induced colitis compared with control littermates. Neutrophil infiltration in the colonic mucosa is attenuated in alpha-mannosidase II (DELTA intestinal epithelial cell) mice. Gene expression levels of neutrophil-attracting chemokines are downregulated in the colonic tissue | Mus musculus |
physiological function | the enzyme plays a crucial, but not exclusive, role in the maturation of N-glycans. Intestinal epithelial cell alpha-mannosidase II promotes intestinal inflammation by facilitating chemokine expression | Mus musculus |