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Literature summary for 3.2.1.114 extracted from

  • Ferrara, C.; Bruenker, P.; Suter, T.; Moser, S.; Puentener, U.; Umana, P.
    Modulation of therapeutic antibody effector functions by glycosylation engineering: influence of Golgi enzyme localization domain and co-expression of heterologous beta1,4-N-acetylglucosaminyltransferase III and Golgi alpha-mannosidase II (2006), Biotechnol. Bioeng., 93, 851-861.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
R60Q/R73N/L79S/E81S beta1,4-N-acetylglucosaminyltransferase III-ManII mutant with amino acid substitutions in the localization domain of ManII, is expressed in similar amounts as beta1,4-N-acetylglucosaminyltransferase III-ManII, yields antibody glycovariants featuring substantially reduced proportions of bisected non-fucosylated oligosaccharides compared to the non-mutated beta1,4-N-acetylglucosaminyltransferase III-ManII Homo sapiens
R73N/L79S/E81S beta1,4-N-acetylglucosaminyltransferase III-ManII mutant with amino acid substitutions in the localization domain of ManII, is expressed in similar amounts as beta1,4-N-acetylglucosaminyltransferase III-ManII, yields antibody glycovariants featuring substantially reduced proportions of bisected non-fucosylated oligosaccharides compared to the non-mutated beta1,4-N-acetylglucosaminyltransferase III-ManII Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information co-expression of beta1,4-N-acetylglucosaminyltransferase III-ManIII and ManII, or of beta1,4-N-acetylglucosaminyltransferase III and ManII leads to the formation of bisected non-fucosylated glycans of the complex type Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Golgi alpha-mannosidase II
-
 Homo sapiens
ManII
-
 Homo sapiens