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Literature summary for 3.2.1.114 extracted from

  • Francis, B.R.; Paquin, L.; Weinkauf, C.; Jarvis, D.L.
    Biosynthesis and processing of Spodoptera frugiperda alpha-mannosidase III (2002), Glycobiology, 12, 369-377.
    View publication on PubMed
Search for more literature for 3.2.1.114

Inhibitors

Inhibitors Comment Organism Structure
additional information effect of tunicamycin and castanospermine on the production of the 3 forms of alpha-mannosidase III Spodoptera frugiperda

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular at least 3 forms of alpha-mannosidase III, the smallest form accumulates in the extracellular fraction Spodoptera frugiperda
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Golgi apparatus alpha-mannosidase III Spodoptera frugiperda 5794
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Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ alpha-mannosidase III, cobalt-dependent Spodoptera frugiperda

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Spodoptera frugiperda study of biosynthesis and processing of alpha-mannosidase III ?
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 ?

Organism

Organism UniProt Comment Textmining
Spodoptera frugiperda
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 at least 3 different forms of ManIII
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Spodoptera frugiperda
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 Sf-9, alpha-mannosidase III
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Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein alpha-mannosidase III is initially synthesized as a high-mannose glycoprotein precursor, its N-glycans are trimmed as it is transported to the Golgi apparatus, N-glycosylation is required for the production of active enzyme Spodoptera frugiperda
additional information study of biosynthesis and processing of alpha-mannosidase III Spodoptera frugiperda
proteolytic modification a subpopulation of Golgi alpha-mannosidase III appears to be proteolytically cleaved and is secreted in enzymically active form Spodoptera frugiperda

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information alpha-mannosidase III hydrolyzes (Man)5-9(GlcNAc)2, not: GlcNAc(Man)5(GlcNAc)2 Spodoptera frugiperda ?
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 ?
additional information study of biosynthesis and processing of alpha-mannosidase III Spodoptera frugiperda ?
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 ?
pyridylaminated (Man)5(GlcNAc)2 + H2O alpha-mannosidase III Spodoptera frugiperda pyridylaminated (Man)3(GlcNAc)2 + alpha-D-mannose
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 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
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 neutral pH-optimum Spodoptera frugiperda