Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-mannonolactam amidrazone | inhibitor is a mimic of the mannopyranosyl cation and acts as a potent broad spectrum mannosidase inhibitor. In the presence of mannonoamidrazone, most of the oligosaccharides are not processed beyond the high mannose structure | Oryctolagus cuniculus | |
D-mannonolactam amidrazone | inhibitor is a mimic of the mannopyranosyl cation and acts as a potent broad spectrum mannosidase inhibitor. It is inactive against processing glucosidases I and II | Vigna radiata var. radiata | |
additional information | not inhibitory up to 0.25 mM: mannostatin A | Vigna radiata var. radiata |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Vigna radiata var. radiata | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MDCK cell | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-alpha-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] + 4 H2O | - |
Vigna radiata var. radiata | alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-alpha-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] + 4 beta-D-mannopyranose | - |
? | |
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-alpha-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] + 4 H2O | - |
Oryctolagus cuniculus | alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-alpha-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] + 4 beta-D-mannopyranose | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.003 | - |
pH not specified in the publication, temperature not specified in the publication | Oryctolagus cuniculus | D-mannonolactam amidrazone | |
0.004 | - |
pH not specified in the publication, temperature not specified in the publication | Vigna radiata var. radiata | D-mannonolactam amidrazone |