Literature summary for 3.2.1.113 extracted from

Cantu, D.; Nerinckx, W.; Reilly, P.
Theory and computation show that Asp463 is the catalytic proton donor in human endoplasmic reticulum alpha-(1->2)-mannosidase I (2008), Carbohydr. Res., 343, 2235-2242 .

Search for more literature for 3.2.1.113

Protein Variants

Protein Variants	Comment	Organism
D463N	the mutant shows 0.1% of wild type catalytic efficiency	Homo sapiens
D463N/E599Q	the mutant shows 0.0003% of wild type catalytic efficiency	Homo sapiens
E330Q	the mutant shows 3.5% of wild type catalytic efficiency	Homo sapiens
E330Q/E599Q	the mutant shows 0.006% of wild type catalytic efficiency	Homo sapiens
E599Q	the mutant shows 0.0005% of wild type catalytic efficiency	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	-	Homo sapiens	5783	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Man9GlcNAc2 + H2O	Homo sapiens	-	Man8GlcNAc2 (isomer 8A1,2,3B1,3) + D-mannose	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UKM7	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Man9GlcNAc2 + H2O	-	Homo sapiens	Man8GlcNAc2 (isomer 8A1,2,3B1,3) + D-mannose	-	?

Synonyms

Synonyms	Comment	Organism
alpha-(1->2)-mannosidase I	-	Homo sapiens
ManI	-	Homo sapiens

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Release 2023.1 (January 2023)