General Stability | Organism |
---|---|
mannosidase IA and B differ in sensitivity to storage in liver cytoplasmic extracts, no interconversion between mannosidase IA and IB during cellulose phosphate chromatography | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | mannosidase IA and B are quite similar in response to inhibitors | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi membrane | - |
Rattus norvegicus | 139 | - |
membrane | - |
Rattus norvegicus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 4 H2O | Rattus norvegicus | - |
(Man)5GlcNAc + 4 D-mannose | - |
? | |
Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 4 H2O | Rattus norvegicus Wistar | - |
(Man)5GlcNAc + 4 D-mannose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male | - |
Rattus norvegicus | - |
Wistar | - |
Rattus norvegicus Wistar | - |
Wistar | - |
Purification (Comment) | Organism |
---|---|
partial | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
Storage Stability | Organism |
---|---|
2-4°C, in 10 mM potassium phosphate buffer, pH 7.2, 1% Triton X-100, 20% loss within 4 weeks | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GlcNAc-(Man)5GlcNAc + H2O | poor substrate | Rattus norvegicus | ? + D-mannose | - |
? | |
Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 4 H2O | - |
Rattus norvegicus | (Man)5GlcNAc + 4 D-mannose | - |
? | |
Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 4 H2O | best substrate | Rattus norvegicus | (Man)5GlcNAc + 4 D-mannose | - |
? | |
Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 4 H2O | - |
Rattus norvegicus Wistar | (Man)5GlcNAc + 4 D-mannose | - |
? | |
Manalpha(1-2)Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manalpha(1-6)Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)Manbeta(1-4)GlcNAc + 4 H2O | best substrate | Rattus norvegicus Wistar | (Man)5GlcNAc + 4 D-mannose | - |
? | |
Manalpha(1-2)Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manbeta(1-4)GlcNA + H2O | hydrolysis at 39% (mannosidase IB) or 67% (mannosidase IA) the rate of (Man)9GlcNAc hydrolysis | Rattus norvegicus | ? + D-mannose | - |
? | |
Manalpha(1-2)Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manbeta(1-4)GlcNA + H2O | hydrolysis at 39% (mannosidase IB) or 67% (mannosidase IA) the rate of (Man)9GlcNAc hydrolysis | Rattus norvegicus Wistar | ? + D-mannose | - |
? | |
Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-Asn + H2O | hydrolysis at 18-25% the rate of (Man)9GlcNAc hydrolysis | Rattus norvegicus | ? + D-mannose | - |
? | |
Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(Manalpha(1-2)Manalpha(1-3))Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc-Asn + H2O | hydrolysis at 18-25% the rate of (Man)9GlcNAc hydrolysis | Rattus norvegicus Wistar | ? + D-mannose | - |
? | |
Manalpha(1-6)(Manalpha(1-3))Manalpha(1-6)(Manalpha(1-3))Manbeta(1-4)GlcNAc + H2O | without alpha1,2-linked mannose residues: poor substrate | Rattus norvegicus | (Man)4GlcNAc + (Man)3GlcNAc + D-mannose | - |
? | |
additional information | mannosidase IA and B are quite similar in substrate specificity | Rattus norvegicus | ? | - |
? | |
additional information | mannosidase IA and B are quite similar in substrate specificity | Rattus norvegicus Wistar | ? | - |
? | |
p-nitrophenyl-alpha-D-mannoside + H2O | mannosidase IB: poor substrate, mannosidase IA: no substrate | Rattus norvegicus | 4-nitrophenol + D-mannose | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
additional information | - |
mannosidase IA and B differ in thermostability | Rattus norvegicus |
37 | - |
24 h, in 0.1 M sodium acetate buffer, pH 5.8, 30% loss of activity | Rattus norvegicus |
50 | - |
mannosidase IB less stable than IA | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
mannosidase IA and B | Rattus norvegicus |