Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.11 extracted from

  • Ahmad, S.; Tester, R.F.; Corbett, A.; Karkalas, J.
    Dextran and 5-aminosalicylic acid (5-ASA) conjugates: synthesis, characterisation and enzymic hydrolysis (2006), Carbohydr. Res., 341, 2694-2701.
    View publication on PubMed
Search for more literature for 3.2.1.11

Application

Application Comment Organism
medicine less oxidised dextrans conjugating proportionally less 5-aminosalicylic acid successfully hydrolysed by dextranase, suggest their potential applications for the treatment of Crohn’s disease in the distal ileum and proximal colon Penicillium sp.

Organism

Organism UniProt Comment Textmining
Penicillium sp.
-
-
-
Penicillium sp. D5884
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dextran + H2O extent of hydrolysis of 5-aminosalicylic acid-dextran conjugates (secondary amines) by dextranase is in part controlled by the degree of oxidation and by the amount of conjugated 5-aminosalicylic acid. Less oxidised dextrans (12%) conjugating proportionally less 5-aminosalicylic acid are successfully hydrolysed by dextranase Penicillium sp. ?
-
 ?
dextran + H2O extent of hydrolysis of 5-aminosalicylic acid-dextran conjugates (secondary amines) by dextranase is in part controlled by the degree of oxidation and by the amount of conjugated 5-aminosalicylic acid. Less oxidised dextrans (12%) conjugating proportionally less 5-aminosalicylic acid are successfully hydrolysed by dextranase Penicillium sp. D5884 ?
-
 ?
additional information dextrans with a maximum degree of oxidation (93%) giving maximum conjugation of 5-aminosalicylic acid are resistant to dextranase hydrolysis Penicillium sp. ?
-
 ?
additional information dextrans with a maximum degree of oxidation (93%) giving maximum conjugation of 5-aminosalicylic acid are resistant to dextranase hydrolysis Penicillium sp. D5884 ?
-
 ?