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Literature summary for 3.2.1.108 extracted from
- Hormone induced expression of brush border lactase in suckling rat intestine (2008), Mol. Cell. Biochem., 312, 11-16.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cortisone | administration of cortisone to 8-day-old pups augments lactase activity | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| thyroxine | administration of thyroxine to 8-day-old pups shows a decline in lactase activity | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| brush border | brush border membrane | Rattus norvegicus | 5903 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 220000 | - |
determined by SDS-PAGE and Western blot | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| lactose + H2O | Rattus norvegicus | - |
D-galactose + D-glucose | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.17 | - |
administration of thyroxine to 8-day-old pups, activity in suckling rat intestine | Rattus norvegicus |
| 0.27 | - |
control | Rattus norvegicus |
| 0.29 | - |
administration of insuline to 8-day-old pups, activity in suckling rat intestine | Rattus norvegicus |
| 0.36 | - |
administration of cortisone to 8-day-old pups, activity in suckling rat intestine | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| lactose + H2O | - |
Rattus norvegicus | D-galactose + D-glucose | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lactase | - |
Rattus norvegicus |
| lactase-phlorizin hydrolase | - |
Rattus norvegicus |
| LPH | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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