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Literature summary for 3.2.1.106 extracted from

  • Herscovics, A.
    Processing glycosidases of Saccharomyces cerevisiae (1999), Biochim. Biophys. Acta, 1426, 275-285.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100 about 45% activation of membrane-bound activity, maximum stimulation of membrane-bound activity at 0.5% Triton X-100, no activation of soluble activity Saccharomyces cerevisiae

Application

Application Comment Organism
analysis contributes to knowledge of N-glycan biosynthesis Saccharomyces cerevisiae
pharmacology glucosidase I may be a target for antiviral and antitumor drugs, glucosidase I inhibitors are potentially useful as antiviral, antitumor and antimetastatic agents Mammalia

Cloned(Commentary)

Cloned (Comment) Organism
CWH41 gene, encodes yeast glucosidase I Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
1-deoxynojirimycin strong inhibition Mammalia
1-deoxynojirimycin strong inhibition Saccharomyces cerevisiae
castanospermine
-
Mammalia
castanospermine
-
Saccharomyces cerevisiae
kojibiose
-
Saccharomyces cerevisiae
Tris
-
Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum endoplasmic reticulum-resident glycoprotein Mammalia 5783
-
endoplasmic reticulum endoplasmic reticulum-resident glycoprotein Saccharomyces cerevisiae 5783
-
membrane type-II transmembrane protein Mammalia 16020
-
membrane type-II transmembrane protein Saccharomyces cerevisiae 16020
-
additional information X-2180, equally distributed between particulate and supernatant fractions Saccharomyces cerevisiae
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information no requirement for divalent cations Mammalia
additional information no requirement for divalent cations Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
95000
-
proteolytically generated soluble form of the enzyme, SDS-PAGE Saccharomyces cerevisiae
107000
-
cloned CWH41 gene encodes a type-II transmembrane protein, Cwh41p, of 107 kDa, SDS-PAGE Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Glc3Man9GlcNAc2 + H2O Mammalia hydrolyses specifically terminal alpha1,2-linked glucose residue ?
-
?
Glc3Man9GlcNAc2 + H2O Saccharomyces cerevisiae hydrolyses specifically terminal alpha1,2-linked glucose residue ?
-
?
additional information Saccharomyces cerevisiae indirect role in cell wall beta1,6-glucan biosynthesis and/or in beta1,6-glucan insertion into the cell wall ?
-
?
additional information Mammalia trimming of the glucose residues is identical in Saccharomyces cerevisiae and in mammalian cells ?
-
?
additional information Saccharomyces cerevisiae trimming of the glucose residues is identical in Saccharomyces cerevisiae and in mammalian cells ?
-
?

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-
Saccharomyces cerevisiae
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Saccharomyces cerevisiae

Purification (Commentary)

Purification (Comment) Organism
partial Saccharomyces cerevisiae
partial, soluble glucosidase I Saccharomyces cerevisiae

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-D-Glc-(1-2)-alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3 + H2O synthetic trisaccharide Saccharomyces cerevisiae beta-D-glucose + alpha-D-Glc-(1-3)-alpha-D-Glc-O(CH2)8-COOCH3
-
?
Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Mammalia D-glucose + Glc2Man9GlcNAc2
-
?
Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Saccharomyces cerevisiae D-glucose + Glc2Man9GlcNAc2
-
?
Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Mammalia ?
-
?
Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Saccharomyces cerevisiae ?
-
?
additional information Glc1Man9GlcNAc2: not a substrate Saccharomyces cerevisiae ?
-
?
additional information also acts, more slowly, on the corresponding glycolipids and glycopeptides Mammalia ?
-
?
additional information also acts, more slowly, on the corresponding glycolipids and glycopeptides Saccharomyces cerevisiae ?
-
?
additional information p-nitrophenyl-alpha-D-glucopyranoside: not a substrate Saccharomyces cerevisiae ?
-
?
additional information Glc2Man9GlcNAc2: not a substrate Saccharomyces cerevisiae ?
-
?
additional information indirect role in cell wall beta1,6-glucan biosynthesis and/or in beta1,6-glucan insertion into the cell wall Saccharomyces cerevisiae ?
-
?
additional information trimming of the glucose residues is identical in Saccharomyces cerevisiae and in mammalian cells Mammalia ?
-
?
additional information trimming of the glucose residues is identical in Saccharomyces cerevisiae and in mammalian cells Saccharomyces cerevisiae ?
-
?

Subunits

Subunits Comment Organism
? x * 95000, SDS-PAGE, reducing conditions Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
CWH41
-
Saccharomyces cerevisiae
Cwh41p calcofluor white hypersensitivity Saccharomyces cerevisiae
Cwh41p CWH41 gene encodes a type-II transmembrane protein, Cwh41p Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
-
Saccharomyces cerevisiae