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Literature summary for 3.2.1.106 extracted from

  • Grinna, L.S.; Robbins, P.W.
    Substrate specificities of rat liver microsomal glucosidases which process glycoproteins (1980), J. Biol. Chem., 255, 2255-2258.
    View publication on PubMed
Search for more literature for 3.2.1.106

Inhibitors

Inhibitors Comment Organism Structure
D-mannose 1 mM: 4% inhibition, 25 mM: 60% inhibition Rattus norvegicus
Man9GlcNAc 1 mM thyroglobulin-derived Man9GlcNAc: 22% inhibition Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum cisternal surface of endoplasmic reticulum Rattus norvegicus 5783
-
membrane microsomal membranes Rattus norvegicus 16020
-
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Glc3Man9GlcNAc2 + H2O Rattus norvegicus hydrolyses specifically terminal alpha1,2-linked glucose residue ?
-
 ?
Glc3Man9GlcNAc2 + H2O Rattus norvegicus specific involvement in the N-linked oligosaccharide-processing pathway ?
-
 ?
Glc3Man9GlcNAc2 + H2O Rattus norvegicus involved in processing of asparagine-linked oligosaccharides ?
-
 ?
additional information Rattus norvegicus involved in processing of asparagine-linked oligosaccharides ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Glc3Man5GlcNAc + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Rattus norvegicus D-glucose + Glc2Man5GlcNAc
-
 ?
Glc3Man5GlcNAc + H2O 11% activity compared with Glc3Man9GlcNAc Rattus norvegicus D-glucose + Glc2Man5GlcNAc
-
 ?
Glc3Man6GlcNAc + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Rattus norvegicus D-glucose + Glc2Man6GlcNAc
-
 ?
Glc3Man6GlcNAc + H2O 15% activity compared with Glc3Man9GlcNAc Rattus norvegicus D-glucose + Glc2Man6GlcNAc
-
 ?
Glc3Man7GlcNAc + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Rattus norvegicus D-glucose + Glc2Man7GlcNAc
-
 ?
Glc3Man7GlcNAc + H2O 30% activity compared with Glc3Man9GlcNAc Rattus norvegicus D-glucose + Glc2Man7GlcNAc
-
 ?
Glc3Man8GlcNAc + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Rattus norvegicus D-glucose + Glc2Man8GlcNAc
-
 ?
Glc3Man8GlcNAc + H2O 85% activity compared with Glc3Man9GlcNAc Rattus norvegicus D-glucose + Glc2Man8GlcNAc
-
 ?
Glc3Man9GlcNAc + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Rattus norvegicus D-glucose + Glc2Man9GlcNAc
-
 ?
Glc3Man9GlcNAc + H2O very good substrate: activity is highest against free oligosaccharide which contains a single N-acetylglucosamine at the reducing end and is lowered about 10% by the presence of a second N-acetylglucosamine at the reducing end Rattus norvegicus D-glucose + Glc2Man9GlcNAc
-
 ?
Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Rattus norvegicus D-glucose + Glc2Man9GlcNAc2
-
 ?
Glc3Man9GlcNAc2 + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Rattus norvegicus ?
-
 ?
Glc3Man9GlcNAc2 + H2O specific involvement in the N-linked oligosaccharide-processing pathway Rattus norvegicus ?
-
 ?
Glc3Man9GlcNAc2 + H2O involved in processing of asparagine-linked oligosaccharides Rattus norvegicus ?
-
 ?
Glc3Man9GlcNAc2-lipid + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Rattus norvegicus D-glucose + Glc2Man9GlcNAc2-lipid
-
 ?
Glc3Man9GlcNAc2-lipid + H2O lower activity than towards free oligosaccharide substrates Rattus norvegicus D-glucose + Glc2Man9GlcNAc2-lipid
-
 ?
Glc3Man9GlcNAc2-peptide + H2O hydrolyses specifically terminal alpha1,2-linked glucose residue Rattus norvegicus D-glucose + Glc2Man9GlcNAc2-peptide
-
 ?
Glc3Man9GlcNAc2-peptide + H2O lower activity than towards free oligosaccharide substrates Rattus norvegicus D-glucose + Glc2Man9GlcNAc2-peptide
-
 ?
additional information also acts, more slowly, on the corresponding glycolipids and glycopeptides Rattus norvegicus ?
-
 ?
additional information comparison of free and linked oligosaccharides as substrates: activity is lower against linked substrates than against free substrates Rattus norvegicus ?
-
 ?
additional information substrate specificities Rattus norvegicus ?
-
 ?
additional information involved in processing of asparagine-linked oligosaccharides Rattus norvegicus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Rattus norvegicus