Application | Comment | Organism |
---|---|---|
medicine | the enzyme can serve as therapeutic target for the treatment of digestive disorders or their sequelae | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,3S,4S)-1-[(2S,3S)-2,4-dihydroxy-3-(tridecyloxy)butyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium | - |
Homo sapiens | |
(2R,3S,4S)-1-[(2S,3S)-2,4-dihydroxy-3-methoxybutyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium | - |
Homo sapiens | |
(2R,3S,4S)-1-[(2S,3S)-3-(benzyloxy)-2,4-dihydroxybutyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium | - |
Homo sapiens | |
(2R,3S,4S)-1-[(2S,3S)-3-ethoxy-2,4-dihydroxybutyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium | - |
Homo sapiens | |
3'-O-methylponkoranol | inhibits the different subunits to different extents, with extraordinary selectivity for C-terminal subunit of the enzyme | Homo sapiens | |
de-O-sulfonated kotalanol | - |
Homo sapiens | |
de-O-sulfonated ponkoranol | - |
Homo sapiens | |
de-O-sulfonated salacinol | - |
Homo sapiens | |
kotalanol | - |
Homo sapiens | |
salacinol | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
brush border | the enzyme is anchored to brush border epithelial cells | Homo sapiens | 5903 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | - |
Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
isomaltase | - |
Homo sapiens |
sucrase isomaltase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000007 | - |
3'-O-methylponkoranol | versus the C-terminal subunit, pH and temperature not specified in the publication | Homo sapiens | |
0.000035 | - |
3'-O-methylponkoranol | versus the N-terminal subunit, pH and temperature not specified in the publication | Homo sapiens | |
0.000103 | - |
de-O-sulfonated ponkoranol | versus the C-terminal subunit, pH and temperature not specified in the publication | Homo sapiens | |
0.000302 | - |
de-O-sulfonated ponkoranol | versus the N-terminal subunit, pH and temperature not specified in the publication | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.14 | - |
pH and temperature not specified in the publication | Homo sapiens | (2R,3S,4S)-1-[(2S,3S)-3-(benzyloxy)-2,4-dihydroxybutyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium | |
0.27 | - |
pH and temperature not specified in the publication | Homo sapiens | (2R,3S,4S)-1-[(2S,3S)-3-ethoxy-2,4-dihydroxybutyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium | |
0.3 | - |
pH and temperature not specified in the publication | Homo sapiens | de-O-sulfonated salacinol | |
0.39 | - |
pH and temperature not specified in the publication | Homo sapiens | (2R,3S,4S)-1-[(2S,3S)-2,4-dihydroxy-3-methoxybutyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium | |
0.95 | - |
pH and temperature not specified in the publication | Homo sapiens | (2R,3S,4S)-1-[(2S,3S)-2,4-dihydroxy-3-(tridecyloxy)butyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium | |
1.3 | - |
pH and temperature not specified in the publication | Homo sapiens | salacinol |