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Literature summary for 3.2.1.10 extracted from

  • Eskandari, R.; Jones, K.; Rose, D.R.; Pinto, B.M.
    Selectivity of 3-O-methylponkoranol for inhibition of N- and C-terminal maltase glucoamylase and sucrase isomaltase, potential therapeutics for digestive disorders or their sequelae (2011), Bioorg. Med. Chem. Lett., 21, 6491-6494.
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme can serve as therapeutic target for the treatment of digestive disorders or their sequelae Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2R,3S,4S)-1-[(2S,3S)-2,4-dihydroxy-3-(tridecyloxy)butyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium
-
Homo sapiens
(2R,3S,4S)-1-[(2S,3S)-2,4-dihydroxy-3-methoxybutyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium
-
Homo sapiens
(2R,3S,4S)-1-[(2S,3S)-3-(benzyloxy)-2,4-dihydroxybutyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium
-
Homo sapiens
(2R,3S,4S)-1-[(2S,3S)-3-ethoxy-2,4-dihydroxybutyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium
-
Homo sapiens
3'-O-methylponkoranol inhibits the different subunits to different extents, with extraordinary selectivity for C-terminal subunit of the enzyme Homo sapiens
de-O-sulfonated kotalanol
-
Homo sapiens
de-O-sulfonated ponkoranol
-
Homo sapiens
de-O-sulfonated salacinol
-
Homo sapiens
kotalanol
-
Homo sapiens
salacinol
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
brush border the enzyme is anchored to brush border epithelial cells Homo sapiens 5903
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
Homo sapiens
-
small intestine
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
isomaltase
-
Homo sapiens
sucrase isomaltase
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000007
-
3'-O-methylponkoranol versus the C-terminal subunit, pH and temperature not specified in the publication Homo sapiens
0.000035
-
3'-O-methylponkoranol versus the N-terminal subunit, pH and temperature not specified in the publication Homo sapiens
0.000103
-
de-O-sulfonated ponkoranol versus the C-terminal subunit, pH and temperature not specified in the publication Homo sapiens
0.000302
-
de-O-sulfonated ponkoranol versus the N-terminal subunit, pH and temperature not specified in the publication Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.14
-
pH and temperature not specified in the publication Homo sapiens (2R,3S,4S)-1-[(2S,3S)-3-(benzyloxy)-2,4-dihydroxybutyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium
0.27
-
pH and temperature not specified in the publication Homo sapiens (2R,3S,4S)-1-[(2S,3S)-3-ethoxy-2,4-dihydroxybutyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium
0.3
-
pH and temperature not specified in the publication Homo sapiens de-O-sulfonated salacinol
0.39
-
pH and temperature not specified in the publication Homo sapiens (2R,3S,4S)-1-[(2S,3S)-2,4-dihydroxy-3-methoxybutyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium
0.95
-
pH and temperature not specified in the publication Homo sapiens (2R,3S,4S)-1-[(2S,3S)-2,4-dihydroxy-3-(tridecyloxy)butyl]-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium
1.3
-
pH and temperature not specified in the publication Homo sapiens salacinol