Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme inhibition by lotus leaf flavonoids, LLF, commercial leaf extract preparation including the aglycones quercetin, myricetin, kaempferol, isorhamnetin and diosmetin, inhibitory kinetics and mechanism of flavonoids from lotus (Nelumbo nucifera Gaertn.) leaf against pancreatic alpha-amylase, overview. Binding analysis reveals that binding of LLF to alpha-amylase changes the conformation and microenvironment of alpha-amylase, resulting in inhibition of the enzyme activity. Thus LLF have the potential to be an ingredient in functional food for the prevention of type-2 diabetes. The crude extract of Nelumbo nucifera Gaertn. leaf flavonoids show high inhibitory activity against porcine pancreatic alpha-amylase with IC50 values of 2.20 mg/ml in vitro biochemistry tests | Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | thermodynamic and kinetic analysis, overview | Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | P00690 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | from porcine pancreas | Sus scrofa | - |
pancreas | - |
Sus scrofa | - |
Synonyms | Comment | Organism |
---|---|---|
LLF-alpha-amylase | - |
Sus scrofa |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.9 | - |
assay at | Sus scrofa |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibitory kinetic analysis, overview | Sus scrofa |