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Literature summary for 3.2.1.1 extracted from

  • Lo Piparo, E.; Scheib, H.; Frei, N.; Williamson, G.; Grigorov, M.; Chou, C.J.
    Flavonoids for controlling starch digestion: structural requirements for inhibiting human alpha-amylase (2008), J. Med. Chem., 51, 3555-3561.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acacetin a flavone, 0.888 mM, pH 6.0, room temperature, 14.1% maximum inhibition Homo sapiens
acarbose 0.888 mM, pH 6.0, room temperature, 99.2% maximum inhibition Homo sapiens
catechin a flavonol, 0.888 mM, pH 6.0, room temperature, 13.1% maximum inhibition Homo sapiens
daidzein a isoflavone, 0.888 mM, pH 6.0, room temperature, 23.3% maximum inhibition Homo sapiens
diosmetin a flavone, 0.888 mM, pH 6.0, room temperature, 19.2% maximum inhibition Homo sapiens
epicatechin a flavonol, 0.888 mM, pH 6.0, room temperature, 10.3% maximum inhibition Homo sapiens
eupafolin a flavone, 0.888 mM, pH 6.0, room temperature, 99.4% maximum inhibition Homo sapiens
fisetin a flavonol, 0.888 mM, pH 6.0, room temperature, 85.6% maximum inhibition Homo sapiens
genistein a isoflavone, 0.888 mM, pH 6.0, room temperature, 25.1% maximum inhibition Homo sapiens
genkwanin a flavone, 0.888 mM, pH 6.0, room temperature, 17.5% maximum inhibition Homo sapiens
hesperetin a flavanone, 0.888 mM, pH 6.0, room temperature, 39.8% maximum inhibition Homo sapiens
isorhamnetin a flavonol, 0.888 mM, pH 6.0, room temperature, 35.4% maximum inhibition Homo sapiens
kaempferol a flavonol, 0.888 mM, pH 6.0, room temperature, 34.5% maximum inhibition Homo sapiens
luteolin a flavone, 0.888 mM, pH 6.0, room temperature, 88.8% maximum inhibition Homo sapiens
additional information the inhibitory activity of the flavonoids toward human alpha-amylase depends on the formation of 1. hydrogen bonds between the hydroxyl groups in position R7 and/or R4' of the polyphenol ligands and the catalytic residues of the binding site Asp197 and Glu233 and 2. formation of a conjugated pi-system between either the AC- or B-ring system and Trp59, that stabilizes the interaction with the active site Homo sapiens
myricetin a flavonol, 0.888 mM, pH 6.0, room temperature, 79% maximum inhibition Homo sapiens
naringenin a flavanone, 0.888 mM, pH 6.0, room temperature, 26.9% maximum inhibition Homo sapiens
quercetagetin a flavonol, 0.888 mM, pH 6.0, room temperature, 97.6% maximum inhibition Homo sapiens
quercetin a flavonol, 0.888 mM, pH 6.0, room temperature, 82.1% maximum inhibition Homo sapiens
Rhamnetin a flavonol, 0.888 mM, pH 6.0, room temperature, 8.1% maximum inhibition Homo sapiens
scutellarein a flavone, 0.888 mM, pH 6.0, room temperature, 98.4% maximum inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Homo sapiens
-
saliva
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
starch + H2O potato starch, pH 6.0, room temperature Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
alpha-amylase type IX-A Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
not detectable for kaempferol, isorhamnetin, rhamnetin, genkwarin, diosmetin, acacetin, catechin, epicatechin, hesperetin, naringenin, genistein, and daidzein Homo sapiens additional information
0.000996
-
pH 6.0, room temperature Homo sapiens acarbose
0.00964
-
a flavone, pH 6.0, room temperature Homo sapiens scutellarein
0.0102
-
a flavonol, pH 6.0, room temperature Homo sapiens quercetagetin
0.0184
-
a flavone, pH 6.0, room temperature Homo sapiens luteolin
0.0196
-
a flavonol, pH 6.0, room temperature Homo sapiens fisetin
0.0214
-
a flavonol, pH 6.0, room temperature Homo sapiens quercetin
0.0302
-
a flavonol, pH 6.0, room temperature Homo sapiens myricetin
0.048
-
a flavone, pH 6.0, room temperature Homo sapiens eupafolin