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Literature summary for 3.2.1.1 extracted from

  • Funke, I.; Melzig, M.F.
    Effect of different phenolic compounds on alpha-amylase activity: screening by microplate-reader based kinetic assay (2005), Pharmazie, 60, 796-797.
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme is a possible target for treatment of diabetes type 2 Sus scrofa
pharmacology the enzyme is a target for development of specific inhibitors for diabetes type 2 therapy Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
acarbose IC50 is 0.023 mM Sus scrofa
apigenin-7-glucoside IC50 is 0.17 mM Sus scrofa
caffeic acid IC50 is 4.8 mM Sus scrofa
chlorogenic acid IC50 is 1.4 mM Sus scrofa
cynarin IC50 is above 2.0 mM Sus scrofa
dihydrocaffeic acid IC50 is above 14.0 mM Sus scrofa
ferulic acid IC50 is above 5.0 mM Sus scrofa
fisetin IC50 is 0.44 mM Sus scrofa
isochlorogenic acid IC50 is 0.56 mM Sus scrofa
luteolin IC50 is 0.17 mM Sus scrofa
luteolin-7-glucoside IC50 is 0.28 mM Sus scrofa
quinic acid IC50 is above 13.0 mM Sus scrofa
rosmarinic acid IC50 is 1.4 mM Sus scrofa
Sinapic acid IC50 is above 6.7 mM Sus scrofa
Tannic acid IC50 is 0.14 mM Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation from pancreas Sus scrofa
-
pancreas
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
microplate-reader based kinetic assay Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl alpha-D-maltopentaoside + H2O
-
Sus scrofa 4-nitrophenol + alpha-D-maltopentaose
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.023
-
IC50 is 0.023 mM Sus scrofa acarbose
0.14
-
IC50 is 0.14 mM Sus scrofa Tannic acid
0.17
-
IC50 is 0.17 mM Sus scrofa luteolin
0.17
-
IC50 is 0.17 mM Sus scrofa apigenin-7-glucoside
0.28
-
IC50 is 0.28 mM Sus scrofa luteolin-7-glucoside
0.44
-
IC50 is 0.44 mM Sus scrofa fisetin
0.56
-
IC50 is 0.56 mM Sus scrofa isochlorogenic acid
1.4
-
IC50 is 1.4 mM Sus scrofa chlorogenic acid
1.4
-
IC50 is 1.4 mM Sus scrofa rosmarinic acid
2
-
IC50 is above 2.0 mM Sus scrofa cynarin
4.8
-
IC50 is 4.8 mM Sus scrofa caffeic acid
5
-
IC50 is above 5.0 mM Sus scrofa ferulic acid
6.7
-
IC50 is above 6.7 mM Sus scrofa Sinapic acid
13
-
IC50 is above 13.0 mM Sus scrofa quinic acid
14
-
IC50 is above 14.0 mM Sus scrofa dihydrocaffeic acid