Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) Rosetta cells | Leishmania donovani |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ethyl 3-[(2R,3R,4R,5S)-4-(acetyloxy)-3-[(tert-butoxycarbonyl)(methyl)amino]-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]propanoate | 63.62% inhibition at 0.2 mM | Leishmania donovani | |
ethyl 3-[(2R,3R,4R,5S)-4-(acetyloxy)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-[(tert-butoxycarbonyl)(methyl)amino]tetrahydrofuran-2-yl]propanoate | 79.87% inhibition at 0.2 mM | Leishmania donovani | |
ethyl 3-[(2R,3R,4R,5S)-4-(acetyloxy)-5-(6-amino-9H-purin-9-yl)-3-[(tert-butoxycarbonyl)(methyl)amino]tetrahydrofuran-2-yl]propanoate | 57.21% inhibition at 0.2 mM | Leishmania donovani | |
ethyl 3-[(2R,3R,4R,5S)-5-[2-(acetylamino)-6-[(diphenylcarbamoyl)oxy]-9H-purin-9-yl]-4-(acetyloxy)-3-[(tert-butoxycarbonyl)(methyl)amino]tetrahydrofuran-2-yl]propanoate | 87.58% inhibition at 0.2 mM | Leishmania donovani | |
ethyl 3-[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-[(tert-butoxycarbonyl)amino]-4-hydroxytetrahydrofuran-2-yl]propanoate | 81.13% inhibition at 0.2 mM | Leishmania donovani |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
52000 | - |
x * 52000, SDS-PAGE | Leishmania donovani |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-homocysteine + H2O | Leishmania donovani | - |
L-homocysteine + adenosine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania donovani | D3K115 | isolate 2001 | - |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography | Leishmania donovani |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
promastigote | - |
Leishmania donovani | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-homocysteine + H2O | - |
Leishmania donovani | L-homocysteine + adenosine | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 52000, SDS-PAGE | Leishmania donovani |
Synonyms | Comment | Organism |
---|---|---|
AdoHcyase | - |
Leishmania donovani |
S-adenosyl-L-homocysteine hydrolase | - |
Leishmania donovani |
S-AdoHcyase | - |
Leishmania donovani |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Leishmania donovani |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00043 | - |
at pH 7.2 and 37°C | Leishmania donovani | ethyl 3-[(2R,3R,4R,5S)-5-[2-(acetylamino)-6-[(diphenylcarbamoyl)oxy]-9H-purin-9-yl]-4-(acetyloxy)-3-[(tert-butoxycarbonyl)(methyl)amino]tetrahydrofuran-2-yl]propanoate | |
0.0796 | - |
at pH 7.2 and 37°C | Leishmania donovani | ethyl 3-[(2R,3R,4R,5S)-4-(acetyloxy)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-[(tert-butoxycarbonyl)(methyl)amino]tetrahydrofuran-2-yl]propanoate | |
0.0954 | - |
at pH 7.2 and 37°C | Leishmania donovani | ethyl 3-[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-[(tert-butoxycarbonyl)amino]-4-hydroxytetrahydrofuran-2-yl]propanoate | |
0.144 | - |
at pH 7.2 and 37°C | Leishmania donovani | ethyl 3-[(2R,3R,4R,5S)-4-(acetyloxy)-3-[(tert-butoxycarbonyl)(methyl)amino]-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]propanoate | |
0.171 | - |
at pH 7.2 and 37°C | Leishmania donovani | ethyl 3-[(2R,3R,4R,5S)-4-(acetyloxy)-5-(6-amino-9H-purin-9-yl)-3-[(tert-butoxycarbonyl)(methyl)amino]tetrahydrofuran-2-yl]propanoate |