Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.13.2.1 extracted from

  • Converso, A.; Hartingh, T.; Fraley, M.E.; Garbaccio, R.M.; Hartman, G.D.; Huang, S.Y.; Majercak, J.M.; McCampbell, A.; Na, S.J.; Ray, W.J.; Savage, M.J.; Wolffe, C.; Yeh, S.; Yu, Y.; White, R.; Zhang, R.
    Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase (2014), Bioorg. Med. Chem. Lett., 24, 2737-2740.
    View publication on PubMed
Search for more literature for 3.13.2.1

Inhibitors

Inhibitors Comment Organism Structure
(1R,2S,3R)-3-(6-amino-4,5-dihydro-9H-purin-9-yl)cyclopentane-1,2-diol
-
 Homo sapiens
(1R,2S,3R,5R)-3-(6-amino-4,5-dihydro-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol
-
 Homo sapiens
(1R,2S,3S)-3-(4-amino-7-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)-4-fluorocyclopentane-1,2-diol
-
 Homo sapiens
(1R,2S,3S)-3-(8-aminoimidazo[1,2-a]pyrazin-3-yl)cyclopentane-1,2-diol
-
 Homo sapiens
(1R,2S,3S,5S)-3-(4-amino-7-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)-5-methylcyclopentane-1,2-diol
-
 Homo sapiens
(1R,2S,4r)-4-(4-amino-6,7-difluoro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol
-
 Homo sapiens
(1R,2S,4r)-4-(4-amino-6-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol
-
 Homo sapiens
(1R,2S,4r)-4-(4-amino-7-chloro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol
-
 Homo sapiens
(1R,2S,4r)-4-(4-amino-7-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol
-
 Homo sapiens
(1R,2S,4r)-4-(4-amino-7-methyl-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol
-
 Homo sapiens
(1R,2S,4r)-4-(6-amino-2-fluoro-9H-purin-9-yl)cyclopentane-1,2-diol
-
 Homo sapiens
(1S,2R,3S,4S)-4-(4-amino-7-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2,3-triol
-
 Homo sapiens
(1S,2R,5R)-5-(6-amino-4,5-dihydro-9H-purin-9-yl)-3-(chloromethyl)cyclopent-3-ene-1,2-diol
-
 Homo sapiens
(1S,2R,5R)-5-(6-amino-4,5-dihydro-9H-purin-9-yl)cyclopent-3-ene-1,2-diol
-
 Homo sapiens
(1S,2R,5S)-5-(4-amino-7-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)-4-fluorocyclopent-3-ene-1,2-diol
-
 Homo sapiens
(1S,2R,5S)-5-(4-amino-7-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopent-3-ene-1,2-diol
-
 Homo sapiens
(1S,2S,3S,5S)-3-(4-amino-7-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)-5-fluorocyclopentane-1,2-diol
-
 Homo sapiens
neplanocin A
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-homocysteine + H2O Homo sapiens
-
 L-homocysteine + adenosine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-homocysteine + H2O
-
 Homo sapiens L-homocysteine + adenosine
-
 ?

Synonyms

Synonyms Comment Organism
AHCY
-
 Homo sapiens
S-adenosylhomocysteine hydrolase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000015
-
 pH and temperature not specified in the publication Homo sapiens neplanocin A
0.000016
-
 pH and temperature not specified in the publication Homo sapiens (1R,2S,4r)-4-(4-amino-7-chloro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol
0.000024
-
 pH and temperature not specified in the publication Homo sapiens (1S,2R,3S,4S)-4-(4-amino-7-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2,3-triol
0.000041
-
 pH and temperature not specified in the publication Homo sapiens (1R,2S,4r)-4-(4-amino-7-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol
0.000055
-
 pH and temperature not specified in the publication Homo sapiens (1R,2S,3R)-3-(6-amino-4,5-dihydro-9H-purin-9-yl)cyclopentane-1,2-diol
0.000195
-
 pH and temperature not specified in the publication Homo sapiens (1S,2R,5R)-5-(6-amino-4,5-dihydro-9H-purin-9-yl)-3-(chloromethyl)cyclopent-3-ene-1,2-diol
0.000236
-
 pH and temperature not specified in the publication Homo sapiens (1R,2S,4r)-4-(4-amino-7-methyl-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol
0.00025
-
 pH and temperature not specified in the publication Homo sapiens (1R,2S,3S)-3-(8-aminoimidazo[1,2-a]pyrazin-3-yl)cyclopentane-1,2-diol
0.000269
-
 pH and temperature not specified in the publication Homo sapiens (1S,2S,3S,5S)-3-(4-amino-7-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)-5-fluorocyclopentane-1,2-diol
0.000303
-
 pH and temperature not specified in the publication Homo sapiens (1R,2S,3R,5R)-3-(6-amino-4,5-dihydro-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol
0.000455
-
 pH and temperature not specified in the publication Homo sapiens (1R,2S,3S)-3-(4-amino-7-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)-4-fluorocyclopentane-1,2-diol
0.000976
-
 pH and temperature not specified in the publication Homo sapiens (1S,2R,5S)-5-(4-amino-7-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)-4-fluorocyclopent-3-ene-1,2-diol
0.001223
-
 pH and temperature not specified in the publication Homo sapiens (1R,2S,3S,5S)-3-(4-amino-7-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)-5-methylcyclopentane-1,2-diol
0.002124
-
 pH and temperature not specified in the publication Homo sapiens (1R,2S,4r)-4-(6-amino-2-fluoro-9H-purin-9-yl)cyclopentane-1,2-diol
0.003644
-
 pH and temperature not specified in the publication Homo sapiens (1R,2S,4r)-4-(4-amino-6,7-difluoro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol
0.004125
-
 pH and temperature not specified in the publication Homo sapiens (1S,2R,5R)-5-(6-amino-4,5-dihydro-9H-purin-9-yl)cyclopent-3-ene-1,2-diol
0.004827
-
 pH and temperature not specified in the publication Homo sapiens (1R,2S,4r)-4-(4-amino-6-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol
0.00969
-
 pH and temperature not specified in the publication Homo sapiens (1S,2R,5S)-5-(4-amino-7-fluoro-1H-imidazo[4,5-c]pyridin-1-yl)cyclopent-3-ene-1,2-diol