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Literature summary for 3.13.2.1 extracted from
- John Montgomery's legacy: carbocyclic adenosine analogues as SAH hydrolase inhibitors with broad-spectrum antiviral activity (2005), Nucleosides Nucleotides Nucleic Acids, 24, 1395-1415.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | SAH hydrolase is an attractive target for antiparasitic and antiviral drug design | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (-)-5'-noraristeromycin | potent antiviral based on the inhibitory effect on the replication of two reporter viruses, vesicular stomatitis virus and vaccinia virus | Mus musculus |  |
| (6'R)-6'-C-methylneplanocin A | potent antiviral based on the inhibitory effect on the replication of two reporter viruses, vesicular stomatitis virus and vaccinia virus | Mus musculus | |
| 3-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)cyclopentane-1,2-diol | potent antiviral based on the inhibitory effect on the replication of two reporter viruses, vesicular stomatitis virus and vaccinia virus | Mus musculus | |
| 3-(6-amino-9H-purin-9-yl)cyclopentane-1,2-diol | potent antiviral based on the inhibitory effect on the replication of two reporter viruses, vesicular stomatitis virus and vaccinia virus | Mus musculus | |
| 3-deazaneplanocin A | potent antiviral based on the inhibitory effect on the replication of two reporter viruses, vesicular stomatitis virus and vaccinia virus | Mus musculus | |
| 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)cyclopent-3-ene-1,2-diol | potent antiviral based on the inhibitory effect on the replication of two reporter viruses, vesicular stomatitis virus and vaccinia virus | Mus musculus | |
| 5-(6-amino-9H-purin-9-yl)cyclopent-3-ene-1,2-diol | potent antiviral based on the inhibitory effect on the replication of two reporter viruses, vesicular stomatitis virus and vaccinia virus | Mus musculus | |
| 6'-beta-fluoroaristeromycin | potent antiviral based on the inhibitory effect on the replication of two reporter viruses, vesicular stomatitis virus and vaccinia virus | Mus musculus | |
| carbocyclic 3-deazaadenosine | potent antiviral based on the inhibitory effect on the replication of two reporter viruses, vesicular stomatitis virus and vaccinia virus | Mus musculus | |
| neplanocin A | potent antiviral based on the inhibitory effect on the replication of two reporter viruses, vesicular stomatitis virus and vaccinia virus | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-homocysteine + H2O | Mus musculus | through the hydrolysis of S-adenosyl-L-homocysteine, the SAH hydrolase prevents the accumulation of S-adenosyl-L-homocysteine that would otherwise lead to an inhibition of the S-adenosyl-L-methionine-dependent methylation reactions, including those that are required for the maturation (i.e. 5'-capping) of viral mRNAs | adenosine + L-homocysteine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-homocysteine + H2O | through the hydrolysis of S-adenosyl-L-homocysteine, the SAH hydrolase prevents the accumulation of S-adenosyl-L-homocysteine that would otherwise lead to an inhibition of the S-adenosyl-L-methionine-dependent methylation reactions, including those that are required for the maturation (i.e. 5'-capping) of viral mRNAs | Mus musculus | adenosine + L-homocysteine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SAH hydrolase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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