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Literature summary for 3.13.2.1 extracted from
- A sensitive isotopic assay method for S-adenosylhomocysteine hydrolase. Some properties of the enzyme from rat liver (1976), Biochim. Biophys. Acta, 438, 522-531.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| L-homocysteine | - |
Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0007 | - |
adenosine | liver enzyme | Rattus norvegicus | |
| 0.08 | - |
L-homocysteine | liver enzyme | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-homocysteine + H2O | Rattus norvegicus | - |
adenosine + L-homocysteine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Wistar rats | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial, liver enzyme | Rattus norvegicus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine | reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestinal mucosa | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0004 | - |
intestinal mucosa enzyme, without adenosine deaminase inhibitor | Rattus norvegicus |
| 0.0052 | - |
intestinal mucosa enzyme, with adenosine deaminase inhibitor | Rattus norvegicus |
| 0.0845 | - |
liver enzyme, without adenosine deaminase inhibitor | Rattus norvegicus |
| 0.0861 | - |
liver enzyme, with adenosine deaminase inhibitor | Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -80°C, intestinal mucosa enzyme, crude preparation, stable for at least 1 week | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-homocysteine + H2O | - |
Rattus norvegicus | adenosine + L-homocysteine | - |
r | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 7.5 | liver enzyme | Rattus norvegicus |
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Release 2023.1 (January 2023)
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